Motif ID: Sox5_Sry

Z-value: 1.499

Transcription factors associated with Sox5_Sry:

Gene SymbolEntrez IDGene Name
Sox5 ENSMUSG00000041540.10 Sox5
Sry ENSMUSG00000069036.3 Sry

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox5mm10_v2_chr6_-_143947061_1439470880.453.2e-03Click!


Activity profile for motif Sox5_Sry.

activity profile for motif Sox5_Sry


Sorted Z-values histogram for motif Sox5_Sry

Sorted Z-values for motif Sox5_Sry



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox5_Sry

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_94044111 10.857 ENSMUST00000132079.1
 Spag9
sperm associated antigen 9
chr10_+_69706326 10.409 ENSMUST00000182992.1
 Ank3
ankyrin 3, epithelial
chr2_-_6722187 10.341 ENSMUST00000182657.1
 Celf2
CUGBP, Elav-like family member 2
chr1_+_34005872 9.969 ENSMUST00000182296.1
 Dst
dystonin
chr5_+_17574268 9.221 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr9_+_27790947 7.682 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr6_+_17491216 6.730 ENSMUST00000080469.5
 Met
met proto-oncogene
chr4_-_82505707 6.694 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr9_-_49798729 6.584 ENSMUST00000166811.2
 Ncam1
neural cell adhesion molecule 1
chr9_-_49798905 6.540 ENSMUST00000114476.2
 Ncam1
neural cell adhesion molecule 1
chr3_+_101377074 6.269 ENSMUST00000043983.5
 Igsf3
immunoglobulin superfamily, member 3
chr12_-_99393010 6.256 ENSMUST00000177451.1
 Foxn3
forkhead box N3
chr12_+_29528382 6.092 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr1_-_64121389 6.054 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr2_-_6721890 6.050 ENSMUST00000114927.2
 Celf2
CUGBP, Elav-like family member 2
chr1_+_19103022 6.011 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr1_-_119837613 5.997 ENSMUST00000064091.5
 Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr5_+_66968559 5.317 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr2_-_60125651 5.150 ENSMUST00000112550.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr2_+_102658640 4.810 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 190 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 32.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.6 20.7 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
4.0 15.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 15.7 GO:0006376 mRNA splice site selection(GO:0006376)
4.4 13.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 11.4 GO:0048813 dendrite morphogenesis(GO:0048813)
0.5 10.0 GO:0008090 retrograde axonal transport(GO:0008090)
1.5 9.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 8.3 GO:0006470 protein dephosphorylation(GO:0006470)
1.0 6.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.6 6.4 GO:0042572 retinol metabolic process(GO:0042572)
0.4 6.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 6.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 6.3 GO:0032808 lacrimal gland development(GO:0032808)
0.5 6.0 GO:0042118 endothelial cell activation(GO:0042118)
0.7 5.6 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.6 5.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.7 4.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.2 4.7 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.8 4.7 GO:0042276 error-prone translesion synthesis(GO:0042276)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 32.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 30.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 17.0 GO:0031225 anchored component of membrane(GO:0031225)
0.8 15.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
2.5 10.0 GO:0031673 H zone(GO:0031673)
0.2 6.2 GO:0030425 dendrite(GO:0030425)
0.0 6.1 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 5.7 GO:0032993 protein-DNA complex(GO:0032993)
0.3 5.4 GO:0031430 M band(GO:0031430)
0.1 5.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 5.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 4.8 GO:0030673 axolemma(GO:0030673)
0.1 4.8 GO:0031519 PcG protein complex(GO:0031519)
0.8 4.7 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.3 4.7 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 4.7 GO:0030054 cell junction(GO:0030054)
0.2 4.6 GO:0071565 nBAF complex(GO:0071565)
0.5 4.4 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 4.4 GO:0032420 stereocilium(GO:0032420)
0.5 4.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 37.0 GO:0030507 spectrin binding(GO:0030507)
0.1 26.6 GO:0008017 microtubule binding(GO:0008017)
1.3 18.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.3 17.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.7 14.2 GO:0030275 LRR domain binding(GO:0030275)
0.7 14.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 14.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.6 11.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 7.3 GO:0003714 transcription corepressor activity(GO:0003714)
1.7 6.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 6.6 GO:0003712 transcription cofactor activity(GO:0003712)
0.1 6.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.9 6.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 6.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 6.1 GO:0050897 cobalt ion binding(GO:0050897)
1.5 6.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 5.5 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
0.1 5.2 GO:0032452 histone demethylase activity(GO:0032452)
0.8 4.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.1 4.4 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 18.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 17.4 PID_FGF_PATHWAY FGF signaling pathway
0.3 15.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 14.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 6.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 5.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 5.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 4.2 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 3.0 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 2.1 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 1.6 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.2 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 1.1 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 1.0 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 32.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 15.9 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 13.6 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 9.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 7.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 6.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 6.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 4.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 4.3 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.3 4.2 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 3.7 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 3.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 3.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 2.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 2.8 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.8 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 2.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 2.4 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 2.2 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter