Motif ID: Sox6_Sox9

Z-value: 0.808

Transcription factors associated with Sox6_Sox9:

Gene SymbolEntrez IDGene Name
Sox6 ENSMUSG00000051910.7 Sox6
Sox9 ENSMUSG00000000567.5 Sox9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9mm10_v2_chr11_+_112782182_112782248-0.435.1e-03Click!
Sox6mm10_v2_chr7_-_116038734_116038750-0.192.2e-01Click!


Activity profile for motif Sox6_Sox9.

activity profile for motif Sox6_Sox9


Sorted Z-values histogram for motif Sox6_Sox9

Sorted Z-values for motif Sox6_Sox9



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox6_Sox9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_29528382 6.248 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr13_-_97747399 5.119 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr8_-_84773381 4.358 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr9_+_27790947 4.157 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr5_+_66968559 4.119 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr18_+_37484955 3.990 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr7_+_96210107 3.752 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr5_+_3928033 3.557 ENSMUST00000143365.1
 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr6_+_17463749 3.442 ENSMUST00000115443.1
 Met
met proto-oncogene
chr10_-_83534130 3.306 ENSMUST00000020497.7
 Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr5_+_66968416 3.167 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr6_+_86404336 3.146 ENSMUST00000113713.2
ENSMUST00000113708.1
 Tia1

cytotoxic granule-associated RNA binding protein 1

chr10_+_69534039 3.054 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr1_-_56972437 3.019 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr1_-_64122256 3.011 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr18_-_23038656 2.992 ENSMUST00000081423.6
 Nol4
nucleolar protein 4
chr6_+_86404257 2.839 ENSMUST00000095752.2
ENSMUST00000130967.1
 Tia1

cytotoxic granule-associated RNA binding protein 1

chr17_-_68004075 2.769 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr13_-_97747373 2.675 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr6_+_86404219 2.663 ENSMUST00000095754.3
ENSMUST00000095753.2
 Tia1

cytotoxic granule-associated RNA binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.7 GO:0007416 synapse assembly(GO:0007416)
0.9 8.6 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
1.1 6.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3 5.8 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.3 5.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 4.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 4.3 GO:0048813 dendrite morphogenesis(GO:0048813)
1.4 4.1 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.6 4.1 GO:0044838 cell quiescence(GO:0044838)
0.9 3.8 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.1 3.8 GO:0016574 histone ubiquitination(GO:0016574)
0.1 3.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.5 3.4 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
1.1 3.3 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.3 3.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.3 3.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 3.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.6 2.9 GO:0046684 response to pyrethroid(GO:0046684)
0.7 2.8 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 2.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.6 GO:0097165 nuclear stress granule(GO:0097165)
2.4 7.2 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 6.2 GO:0005871 kinesin complex(GO:0005871)
0.1 6.0 GO:0009925 basal plasma membrane(GO:0009925)
1.4 5.8 GO:0044307 dendritic branch(GO:0044307)
0.0 5.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 4.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 4.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.4 3.8 GO:0001739 sex chromatin(GO:0001739)
0.1 3.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 3.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 3.1 GO:0043235 receptor complex(GO:0043235)
0.0 3.0 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.8 GO:0043005 neuron projection(GO:0043005)
0.6 2.5 GO:0005594 FACIT collagen trimer(GO:0005593) collagen type IX trimer(GO:0005594)
0.2 2.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.5 2.3 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.5 2.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.5 2.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.3 GO:0015631 tubulin binding(GO:0015631)
0.2 8.6 GO:0017091 AU-rich element binding(GO:0017091)
0.3 6.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
1.6 6.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.9 6.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.5 6.2 GO:0050897 cobalt ion binding(GO:0050897)
0.1 6.2 GO:0003777 microtubule motor activity(GO:0003777)
0.1 5.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.9 4.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
1.4 4.3 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 3.5 GO:0030507 spectrin binding(GO:0030507)
1.1 3.3 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.4 3.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 3.2 GO:0035497 cAMP response element binding(GO:0035497)
0.2 3.0 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 2.9 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 2.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 2.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 2.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 5.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 4.6 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 4.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 4.2 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID_ATR_PATHWAY ATR signaling pathway
0.1 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 1.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 0.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.7 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 6.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 5.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.4 4.1 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 3.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 3.1 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 2.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 2.1 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.1 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 2.1 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 2.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.9 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 1.8 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.8 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.7 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 1.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription