Motif ID: Sox8

Z-value: 0.393


Transcription factors associated with Sox8:

Gene SymbolEntrez IDGene Name
Sox8 ENSMUSG00000024176.4 Sox8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox8mm10_v2_chr17_-_25570678_25570694-0.471.8e-03Click!


Activity profile for motif Sox8.

activity profile for motif Sox8


Sorted Z-values histogram for motif Sox8

Sorted Z-values for motif Sox8



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox8

PNG image of the network

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Top targets:


Showing 1 to 20 of 51 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_8667033 2.446 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr3_+_102010138 2.127 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr13_+_65512678 1.485 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr18_-_62741387 1.236 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr19_+_24875679 1.172 ENSMUST00000073080.5
 Gm10053
predicted gene 10053
chr7_-_126800354 1.167 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr13_-_19395728 1.074 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chr4_-_58553553 1.008 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr10_-_128180265 0.994 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr7_-_126800036 0.973 ENSMUST00000133514.1
ENSMUST00000151137.1
 Aldoa

aldolase A, fructose-bisphosphate

chr1_+_109993982 0.939 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr1_+_109983737 0.853 ENSMUST00000172005.1
 Cdh7
cadherin 7, type 2
chr11_+_69991633 0.843 ENSMUST00000108592.1
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr13_-_66227573 0.838 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr13_-_66852017 0.807 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr11_-_26591729 0.632 ENSMUST00000109504.1
 Vrk2
vaccinia related kinase 2
chr8_+_34807287 0.607 ENSMUST00000033930.4
 Dusp4
dual specificity phosphatase 4
chr11_+_113659283 0.544 ENSMUST00000137878.1
 Cog1
component of oligomeric golgi complex 1
chr15_-_97020322 0.543 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4
chr14_-_49783327 0.522 ENSMUST00000118129.1
ENSMUST00000036972.6
 3632451O06Rik

RIKEN cDNA 3632451O06 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.4 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.2 2.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 2.1 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 1.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 1.2 GO:0060467 negative regulation of fertilization(GO:0060467)
0.3 1.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 0.6 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0 0.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.5 GO:0007099 centriole replication(GO:0007099)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.0 0.1 GO:2001184 regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.1 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.0 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.1 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 0.5 GO:0071942 XPC complex(GO:0071942)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 0.1 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.4 GO:0035939 microsatellite binding(GO:0035939)
0.4 2.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 2.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 0.6 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.5 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 0.4 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane