Motif ID: Sp1
Z-value: 2.041
Transcription factors associated with Sp1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sp1 | ENSMUSG00000001280.6 | Sp1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp1 | mm10_v2_chr15_+_102406143_102406380 | 0.30 | 5.6e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,124 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 31.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.9 | 30.3 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.5 | 28.5 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 2.9 | 25.9 | GO:0032484 | Ral protein signal transduction(GO:0032484) |
| 3.2 | 22.6 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 2.3 | 22.6 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.7 | 21.9 | GO:0032456 | endocytic recycling(GO:0032456) |
| 5.2 | 20.8 | GO:0044268 | multicellular organismal protein metabolic process(GO:0044268) |
| 5.2 | 20.8 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 1.2 | 20.8 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 3.4 | 20.5 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 1.8 | 20.2 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 1.3 | 20.2 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 2.2 | 19.8 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 2.4 | 19.5 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.8 | 19.4 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.2 | 19.2 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.9 | 18.3 | GO:0021859 | pyramidal neuron differentiation(GO:0021859) |
| 0.4 | 18.3 | GO:0009311 | oligosaccharide metabolic process(GO:0009311) |
| 1.3 | 18.1 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 350 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 298.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.4 | 57.1 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.5 | 50.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.3 | 49.8 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.3 | 48.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 44.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.7 | 39.7 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.3 | 38.3 | GO:0001726 | ruffle(GO:0001726) |
| 0.5 | 25.5 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.2 | 25.0 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 24.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 21.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 1.5 | 21.7 | GO:0043083 | synaptic cleft(GO:0043083) |
| 1.1 | 21.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 21.4 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.2 | 21.3 | GO:0005770 | late endosome(GO:0005770) |
| 1.0 | 21.0 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.6 | 20.1 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.1 | 19.1 | GO:0005773 | vacuole(GO:0005773) |
| 1.5 | 17.5 | GO:0044666 | MLL3/4 complex(GO:0044666) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 619 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 87.7 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.3 | 61.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 37.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.4 | 31.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.7 | 30.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 1.4 | 25.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.3 | 25.3 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.8 | 25.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.6 | 24.9 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.3 | 24.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.8 | 24.8 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 24.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.9 | 23.4 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 1.0 | 22.9 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.4 | 22.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 7.2 | 21.7 | GO:0016964 | alpha-2 macroglobulin receptor activity(GO:0016964) |
| 2.2 | 21.7 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.4 | 20.7 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.6 | 19.8 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 1.1 | 19.2 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 114 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 62.1 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.9 | 46.0 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.3 | 42.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.7 | 36.3 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.2 | 30.3 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.6 | 26.4 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.8 | 24.1 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.9 | 23.7 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.4 | 20.8 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.8 | 18.4 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.4 | 17.8 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.4 | 17.8 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.7 | 15.7 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.6 | 15.4 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 15.0 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 1.0 | 14.0 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.9 | 13.6 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.6 | 12.7 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.4 | 12.7 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.5 | 12.1 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 171 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 57.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.0 | 39.5 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.8 | 34.6 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.4 | 30.7 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.9 | 28.7 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 1.6 | 24.0 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.9 | 21.5 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.5 | 20.0 | REACTOME_GAB1_SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.5 | 20.0 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.0 | 19.8 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.6 | 19.4 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 1.0 | 18.8 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.7 | 16.7 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 1.2 | 16.6 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 1.1 | 16.6 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 16.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 16.0 | REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.6 | 15.8 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.4 | 15.0 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.7 | 14.2 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
