Motif ID: Sp100

Z-value: 3.301


Transcription factors associated with Sp100:

Gene SymbolEntrez IDGene Name
Sp100 ENSMUSG00000026222.10 Sp100

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp100mm10_v2_chr1_+_85650044_856500520.134.3e-01Click!


Activity profile for motif Sp100.

activity profile for motif Sp100


Sorted Z-values histogram for motif Sp100

Sorted Z-values for motif Sp100



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp100

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3023547 68.043 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3013140 66.668 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr14_-_19418930 59.411 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3025417 58.325 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_-_98667264 52.832 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3018753 52.152 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3004457 51.679 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3017408 49.580 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3036877 41.335 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3027439 41.014 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3000922 40.511 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3015654 35.860 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr8_+_94179089 26.206 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr10_-_42583628 16.741 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr13_-_23762378 14.013 ENSMUST00000091701.2
 Hist1h3a
histone cluster 1, H3a
chr16_-_17125106 13.710 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr3_+_135212557 12.354 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr3_-_88410295 12.254 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr4_+_63215402 10.471 ENSMUST00000036300.6
 Col27a1
collagen, type XXVII, alpha 1
chr8_-_4779513 10.351 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 26.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
3.7 26.2 GO:0010273 detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169)
1.3 18.9 GO:0010216 maintenance of DNA methylation(GO:0010216)
3.3 16.7 GO:0021764 amygdala development(GO:0021764)
0.3 12.6 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
2.1 12.4 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1 11.9 GO:0051028 mRNA transport(GO:0051028)
0.6 11.4 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 10.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.7 10.5 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 10.5 GO:0007059 chromosome segregation(GO:0007059)
0.9 9.8 GO:0006228 UTP biosynthetic process(GO:0006228)
1.1 9.5 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 8.9 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.5 8.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
2.8 8.5 GO:1990523 bone regeneration(GO:1990523)
1.2 8.4 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.2 7.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.3 7.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.0 7.1 GO:0030916 otic vesicle formation(GO:0030916)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 315.1 GO:0005575 cellular_component(GO:0005575)
0.8 24.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 13.1 GO:0005925 focal adhesion(GO:0005925)
1.2 12.4 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
2.0 12.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 12.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 11.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.9 10.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 10.5 GO:0001741 XY body(GO:0001741)
0.1 9.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.4 8.5 GO:0031527 filopodium membrane(GO:0031527)
0.1 8.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.7 6.5 GO:0061574 ASAP complex(GO:0061574)
0.7 6.5 GO:0045298 tubulin complex(GO:0045298)
1.6 6.2 GO:0043293 apoptosome(GO:0043293)
1.8 5.5 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.1 5.2 GO:0072686 mitotic spindle(GO:0072686)
0.4 4.9 GO:0010369 chromocenter(GO:0010369)
0.1 4.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 4.8 GO:0005901 caveola(GO:0005901)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 247.5 GO:0003674 molecular_function(GO:0003674)
0.5 26.2 GO:0005507 copper ion binding(GO:0005507)
0.2 16.7 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.3 15.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
2.5 12.4 GO:0043515 kinetochore binding(GO:0043515)
0.3 12.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.9 10.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 10.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 9.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 9.7 GO:0003735 structural constituent of ribosome(GO:0003735)
3.2 9.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.4 8.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 8.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 7.8 GO:0042393 histone binding(GO:0042393)
1.0 7.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.9 7.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.3 7.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 6.5 GO:0005178 integrin binding(GO:0005178)
0.2 6.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.5 5.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.8 PID_PLK1_PATHWAY PLK1 signaling events
0.3 11.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 11.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 10.5 NABA_COLLAGENS Genes encoding collagen proteins
1.1 9.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 8.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.3 8.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 8.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 8.4 PID_ALK1_PATHWAY ALK1 signaling events
0.3 7.6 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 7.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 5.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 5.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 2.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 2.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.1 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.5 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 27.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 16.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 11.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 10.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 9.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.9 9.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 8.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 8.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.8 7.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.6 7.1 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.3 6.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.8 6.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 5.9 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.2 5.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.3 5.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 5.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 5.5 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 5.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 4.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 4.8 REACTOME_SPHINGOLIPID_METABOLISM Genes involved in Sphingolipid metabolism