Motif ID: Sp2
Z-value: 0.568
Transcription factors associated with Sp2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sp2 | ENSMUSG00000018678.6 | Sp2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp2 | mm10_v2_chr11_-_96968655_96968673 | -0.01 | 9.3e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 195 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.9 | GO:0042573 | retinoic acid metabolic process(GO:0042573) |
| 0.1 | 2.5 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.5 | 2.4 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.2 | 2.3 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.2 | 2.0 | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030) |
| 0.0 | 1.9 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.2 | 1.8 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.2 | 1.8 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.6 | 1.7 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.5 | 1.6 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.2 | 1.6 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.1 | 1.6 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 1.5 | GO:0043486 | histone exchange(GO:0043486) |
| 0.0 | 1.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 1.4 | GO:0097402 | neuroblast migration(GO:0097402) |
| 0.2 | 1.4 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.2 | 1.2 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 1.2 | GO:0072540 | T-helper 17 cell lineage commitment(GO:0072540) |
| 0.3 | 1.1 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 0.1 | 1.1 | GO:0006477 | protein sulfation(GO:0006477) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 79 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.4 | 2.5 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.0 | 2.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 2.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.1 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 2.0 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 1.9 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.6 | 1.7 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.2 | 1.6 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 1.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 1.1 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 1.0 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 1.0 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 1.0 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 0.0 | 0.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.9 | GO:0030684 | preribosome(GO:0030684) |
| 0.0 | 0.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.8 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.8 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 132 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.0 | 5.9 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 3.4 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.2 | 2.5 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.1 | 2.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 2.2 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.3 | 2.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.3 | 1.9 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.1 | 1.9 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 1.9 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.2 | 1.8 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.0 | 1.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.3 | 1.6 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 1.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 1.4 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.1 | 1.3 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 1.3 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 1.3 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 1.0 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 1.0 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 27 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.4 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 2.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 2.1 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 1.5 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 1.3 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.2 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 1.0 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 1.0 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.9 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.9 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.7 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.7 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.5 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.0 | 0.4 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.4 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.4 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.3 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 51 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 2.8 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.4 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 2.3 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 2.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.2 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 2.2 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 2.2 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 1.9 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.8 | REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ | Genes involved in Cleavage of Growing Transcript in the Termination Region |
| 0.0 | 1.8 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 1.6 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.1 | 1.4 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 1.3 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 1.3 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.3 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 1.1 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 1.1 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.1 | 1.0 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 1.0 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
