Motif ID: Spi1

Z-value: 0.905


Transcription factors associated with Spi1:

Gene SymbolEntrez IDGene Name
Spi1 ENSMUSG00000002111.8 Spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spi1mm10_v2_chr2_+_91082362_91082390-0.057.8e-01Click!


Activity profile for motif Spi1.

activity profile for motif Spi1


Sorted Z-values histogram for motif Spi1

Sorted Z-values for motif Spi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Spi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_98412461 1.881 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr3_-_95904683 1.829 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr7_-_102250086 1.800 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr19_+_5740885 1.778 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr2_+_59612034 1.716 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr4_-_154636831 1.626 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr5_+_64812336 1.621 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr13_-_41487306 1.608 ENSMUST00000021794.6
 Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr2_+_105682463 1.582 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr2_+_105675478 1.531 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr3_-_101604580 1.525 ENSMUST00000036493.6
 Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_-_45503282 1.523 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr10_+_127725392 1.442 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr1_+_178798438 1.424 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr3_+_89436699 1.417 ENSMUST00000038942.3
ENSMUST00000130858.1
 Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr4_-_82705735 1.408 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr9_+_35423582 1.403 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr10_-_8518801 1.352 ENSMUST00000061601.7
 Ust
uronyl-2-sulfotransferase
chr3_-_127780461 1.307 ENSMUST00000029662.5
ENSMUST00000161239.1
 Alpk1

alpha-kinase 1

chr10_-_83648631 1.270 ENSMUST00000146876.2
ENSMUST00000176294.1
 Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 650 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.2 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.2 2.8 GO:0015701 bicarbonate transport(GO:0015701)
0.3 2.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.7 2.6 GO:0045608 inhibition of neuroepithelial cell differentiation(GO:0002085) negative regulation of auditory receptor cell differentiation(GO:0045608)
0.7 2.6 GO:0044849 estrous cycle(GO:0044849)
0.6 2.6 GO:1903416 response to glycoside(GO:1903416)
0.4 2.5 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 2.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.5 2.1 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.2 2.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 2.1 GO:0007520 myoblast fusion(GO:0007520)
0.5 2.0 GO:0000255 allantoin metabolic process(GO:0000255)
0.6 1.9 GO:0036363 transforming growth factor beta activation(GO:0036363)
0.4 1.9 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.2 1.9 GO:0015670 carbon dioxide transport(GO:0015670)
0.2 1.9 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 1.9 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.3 1.8 GO:0071635 negative regulation of transforming growth factor beta production(GO:0071635)
0.2 1.8 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 1.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 225 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 4.0 GO:0043296 apical junction complex(GO:0043296)
0.0 3.4 GO:0045177 apical part of cell(GO:0045177)
0.1 3.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 3.2 GO:0009925 basal plasma membrane(GO:0009925)
0.1 3.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.1 GO:0031985 Golgi cisterna(GO:0031985)
0.2 2.7 GO:0043219 lateral loop(GO:0043219)
0.1 2.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.3 GO:0005605 basal lamina(GO:0005605)
0.3 2.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 2.0 GO:0072687 meiotic spindle(GO:0072687)
0.1 2.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.4 1.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 1.9 GO:0005915 zonula adherens(GO:0005915)
0.2 1.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 1.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.4 1.6 GO:0008623 CHRAC(GO:0008623)
0.1 1.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 379 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.8 GO:0003682 chromatin binding(GO:0003682)
0.1 5.9 GO:0046332 SMAD binding(GO:0046332)
0.0 5.8 GO:0004386 helicase activity(GO:0004386)
0.3 5.2 GO:0017166 vinculin binding(GO:0017166)
0.1 4.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 4.2 GO:0070410 co-SMAD binding(GO:0070410)
0.1 4.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 3.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 3.1 GO:0001012 RNA polymerase II regulatory region DNA binding(GO:0001012)
0.1 2.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 2.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 2.7 GO:1990239 steroid hormone binding(GO:1990239)
0.1 2.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 2.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 2.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.7 2.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 1.9 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.4 1.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 5.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 5.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 3.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 2.7 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.5 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 2.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.2 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 2.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.3 1.8 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 1.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 4.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 3.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 3.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 2.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.1 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 2.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.7 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.6 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.1 1.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.4 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)