Motif ID: Spib

Z-value: 0.808


Transcription factors associated with Spib:

Gene SymbolEntrez IDGene Name
Spib ENSMUSG00000008193.7 Spib



Activity profile for motif Spib.

activity profile for motif Spib


Sorted Z-values histogram for motif Spib

Sorted Z-values for motif Spib



Network of associatons between targets according to the STRING database.



First level regulatory network of Spib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 4.373 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_+_81021202 3.979 ENSMUST00000117253.1
ENSMUST00000120128.1
 Lphn3

latrophilin 3

chr17_+_93199348 3.732 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr10_-_6980376 2.663 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chrX_-_43167817 2.609 ENSMUST00000115058.1
ENSMUST00000115059.1
 Tenm1

teneurin transmembrane protein 1

chr6_+_137410721 2.531 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr6_-_136941694 2.465 ENSMUST00000032344.5
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr15_-_66812593 2.382 ENSMUST00000100572.3
 Sla
src-like adaptor
chr5_+_149265035 2.206 ENSMUST00000130144.1
ENSMUST00000071130.3
 Alox5ap

arachidonate 5-lipoxygenase activating protein

chr2_+_32721055 2.119 ENSMUST00000074248.4
 Sh2d3c
SH2 domain containing 3C
chr12_-_86988676 2.101 ENSMUST00000095521.2
 Zdhhc22
zinc finger, DHHC-type containing 22
chr3_-_123672321 2.077 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr2_+_121357714 2.058 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr6_-_136941494 1.811 ENSMUST00000111892.1
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_-_52558539 1.807 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr2_+_121358591 1.665 ENSMUST00000000317.6
ENSMUST00000129130.1
 Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr1_-_173333503 1.611 ENSMUST00000038227.4
 Darc
Duffy blood group, chemokine receptor
chr2_+_55437100 1.611 ENSMUST00000112633.2
ENSMUST00000112632.1
 Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr7_+_99535439 1.563 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr12_-_78980758 1.458 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 4.3 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
1.4 4.1 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.0 3.7 GO:0032091 negative regulation of protein binding(GO:0032091)
0.5 3.1 GO:0032796 uropod organization(GO:0032796)
0.1 3.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.5 2.5 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.1 2.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.7 2.2 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.1 2.2 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 2.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.3 2.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.4 1.9 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.2 1.8 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.3 1.6 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 1.6 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 1.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.4 1.4 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.3 1.4 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 1.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0043195 terminal bouton(GO:0043195)
0.0 3.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.4 GO:0043204 perikaryon(GO:0043204)
0.3 3.1 GO:0032426 stereocilium tip(GO:0032426)
0.1 3.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.7 2.2 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.6 2.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 2.2 GO:0030315 T-tubule(GO:0030315)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.1 1.6 GO:0031143 pseudopodium(GO:0031143)
0.2 1.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.3 1.4 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.2 1.4 GO:0097443 sorting endosome(GO:0097443)
0.0 1.3 GO:0008021 synaptic vesicle(GO:0008021)
0.1 1.2 GO:0030478 actin cap(GO:0030478)
0.1 1.1 GO:0071564 npBAF complex(GO:0071564)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.1 1.0 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 4.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 3.9 GO:0030246 carbohydrate binding(GO:0030246)
0.9 3.7 GO:0004111 creatine kinase activity(GO:0004111)
0.2 3.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 3.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 3.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.4 GO:0017124 SH3 domain binding(GO:0017124)
0.3 3.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.4 2.2 GO:0050544 arachidonic acid binding(GO:0050544)
0.2 2.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.2 2.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 2.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.5 2.1 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.2 2.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 2.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 1.7 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.5 1.6 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.3 1.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 4.9 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 3.1 PID_BCR_5PATHWAY BCR signaling pathway
0.1 2.6 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 2.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.1 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.1 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.3 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 0.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.3 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 3.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.5 3.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 2.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 2.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 2.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 2.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.6 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.1 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.0 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM Genes involved in Integration of energy metabolism
0.1 0.9 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 0.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion