Motif ID: Spic

Z-value: 0.721


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_886830250.105.4e-01Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136892867 3.008 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr1_-_56978534 2.685 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr4_-_136886187 2.199 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr11_+_78324200 2.185 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr11_-_106715251 2.163 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr4_-_118489755 2.140 ENSMUST00000184261.1
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr8_-_122432924 1.826 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr12_+_75308308 1.751 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr14_+_80000292 1.718 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr4_+_130913120 1.664 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr15_-_66812593 1.569 ENSMUST00000100572.3
 Sla
src-like adaptor
chr6_+_5725639 1.553 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr17_-_25785533 1.529 ENSMUST00000140738.1
ENSMUST00000145053.1
ENSMUST00000138759.1
ENSMUST00000133071.1
ENSMUST00000077938.3
 Haghl




hydroxyacylglutathione hydrolase-like




chrX_+_8271133 1.497 ENSMUST00000127103.1
ENSMUST00000115591.1
 Slc38a5

solute carrier family 38, member 5

chr4_+_130913264 1.421 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr19_+_4231899 1.304 ENSMUST00000025773.3
 Pold4
polymerase (DNA-directed), delta 4
chr6_-_48708206 1.267 ENSMUST00000119315.1
ENSMUST00000053661.4
 Gimap6

GTPase, IMAP family member 6

chr12_-_4592927 1.214 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr3_+_95526777 1.211 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr17_-_25785324 1.177 ENSMUST00000150324.1
 Haghl
hydroxyacylglutathione hydrolase-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.7 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.3 2.7 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 2.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 2.3 GO:0071569 protein ufmylation(GO:0071569)
0.5 2.2 GO:0050904 diapedesis(GO:0050904)
0.2 2.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 2.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 2.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 2.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 2.0 GO:0045026 plasma membrane fusion(GO:0045026)
0.4 1.8 GO:0033864 positive regulation of NAD(P)H oxidase activity(GO:0033864) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137)
0.1 1.8 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 1.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 1.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.6 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 1.6 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 1.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 1.5 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.1 1.5 GO:0015816 glycine transport(GO:0015816)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0005581 collagen trimer(GO:0005581)
0.1 3.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 2.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.4 1.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 1.7 GO:0042581 specific granule(GO:0042581)
0.5 1.6 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 1.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.2 1.2 GO:0070820 tertiary granule(GO:0070820)
0.2 1.2 GO:1990393 3M complex(GO:1990393)
0.3 1.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.2 1.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 1.0 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.1 1.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.0 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 1.0 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 2.7 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.4 2.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 2.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 2.0 GO:0043394 proteoglycan binding(GO:0043394)
0.5 1.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 1.8 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
0.1 1.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.4 1.3 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.1 1.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 1.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.2 1.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.1 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.7 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 2.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.5 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.2 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.9 5.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 3.2 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.0 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.2 1.6 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.6 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.4 1.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.2 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.1 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.0 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.1 0.6 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins