Motif ID: Stat1

Z-value: 0.785


Transcription factors associated with Stat1:

Gene SymbolEntrez IDGene Name
Stat1 ENSMUSG00000026104.8 Stat1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat1mm10_v2_chr1_+_52119438_521194990.296.7e-02Click!


Activity profile for motif Stat1.

activity profile for motif Stat1


Sorted Z-values histogram for motif Stat1

Sorted Z-values for motif Stat1



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat1

PNG image of the network

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Top targets:


Showing 1 to 20 of 170 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 5.981 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr11_+_78499087 3.970 ENSMUST00000017488.4
 Vtn
vitronectin
chrX_-_61185558 3.440 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr9_-_96719404 3.430 ENSMUST00000140121.1
 Zbtb38
zinc finger and BTB domain containing 38
chr6_+_115134899 3.301 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr1_-_155417394 3.201 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr10_+_69925766 2.844 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chr4_-_108031938 2.740 ENSMUST00000106708.1
 Podn
podocan
chr10_+_69925954 2.692 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr10_+_69925800 2.623 ENSMUST00000182029.1
 Ank3
ankyrin 3, epithelial
chr9_-_96719549 2.580 ENSMUST00000128269.1
 Zbtb38
zinc finger and BTB domain containing 38
chr4_-_108032069 2.544 ENSMUST00000106709.2
 Podn
podocan
chr1_-_155417283 2.462 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr11_+_101245996 2.298 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr16_-_74411776 2.084 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr7_+_24134148 2.000 ENSMUST00000056549.7
 Zfp235
zinc finger protein 235
chr13_+_109903089 1.858 ENSMUST00000120664.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr7_+_82335732 1.855 ENSMUST00000173287.1
 Adamtsl3
ADAMTS-like 3
chr7_+_45783686 1.702 ENSMUST00000118564.1
ENSMUST00000133428.1
 Lmtk3

lemur tyrosine kinase 3

chr7_+_24112314 1.694 ENSMUST00000120006.1
ENSMUST00000005413.3
 Zfp112

zinc finger protein 112


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.7 8.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 6.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.9 5.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 4.5 GO:0006275 regulation of DNA replication(GO:0006275)
0.4 4.0 GO:0097421 liver regeneration(GO:0097421)
0.0 3.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 3.1 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0 2.7 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015)
0.1 2.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 2.6 GO:0034340 response to type I interferon(GO:0034340)
0.0 2.6 GO:0048813 dendrite morphogenesis(GO:0048813)
0.4 2.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.7 2.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 1.9 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 1.5 GO:0046967 cytosol to ER transport(GO:0046967)
0.2 1.5 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 1.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 1.5 GO:0007416 synapse assembly(GO:0007416)
0.1 1.4 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.0 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.4 8.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 6.9 GO:0072562 blood microparticle(GO:0072562)
0.3 6.0 GO:0032279 asymmetric synapse(GO:0032279)
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.8 4.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 3.3 GO:0031201 SNARE complex(GO:0031201)
0.5 2.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 2.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.1 GO:0030673 axolemma(GO:0030673)
0.0 1.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 1.5 GO:0031673 H zone(GO:0031673)
0.2 1.5 GO:0042825 TAP complex(GO:0042825)
0.1 1.5 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 1.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 1.4 GO:0070695 FHF complex(GO:0070695)
0.0 1.4 GO:0055037 recycling endosome(GO:0055037)
0.3 1.2 GO:0090537 CERF complex(GO:0090537)
0.2 1.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 1.0 GO:0016035 zeta DNA polymerase complex(GO:0016035)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 GO:0030507 spectrin binding(GO:0030507)
1.0 6.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 6.0 GO:0008327 methyl-CpG binding(GO:0008327)
1.9 5.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 5.3 GO:0005518 collagen binding(GO:0005518)
0.3 4.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 3.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 3.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 2.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 2.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 2.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.5 2.3 GO:0097643 amylin receptor activity(GO:0097643)
0.5 2.1 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.2 2.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 2.0 GO:0001848 complement binding(GO:0001848)
0.1 1.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 1.5 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.2 1.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 5.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 4.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 4.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 3.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 2.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 2.4 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 1.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.3 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.4 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 0.3 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 6.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 5.0 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.2 3.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 3.3 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 2.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 1.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.7 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 1.5 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.1 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 0.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 0.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex