Motif ID: Stat2

Z-value: 2.760


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.654.7e-06Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_173942445 34.121 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr12_+_103434211 27.538 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr7_-_141010759 21.640 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr3_-_107760221 18.534 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr16_+_23609895 17.206 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr6_+_121245903 17.018 ENSMUST00000032198.9
 Usp18
ubiquitin specific peptidase 18
chr16_+_42907563 16.170 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr16_+_43363855 16.138 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr1_+_153751946 15.456 ENSMUST00000183241.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr16_+_43364145 13.669 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr16_+_43235856 13.482 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr1_+_153751859 13.418 ENSMUST00000182538.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr2_+_4559742 12.757 ENSMUST00000176828.1
 Frmd4a
FERM domain containing 4A
chr1_-_156674290 12.657 ENSMUST00000079625.4
 Tor3a
torsin family 3, member A
chr12_-_78980758 12.548 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr4_-_154636831 12.498 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr15_-_66812593 11.940 ENSMUST00000100572.3
 Sla
src-like adaptor
chr10_+_13966268 11.849 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr1_+_153749496 11.533 ENSMUST00000182722.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr7_-_78578308 11.282 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 65.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
3.0 50.7 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
1.6 40.4 GO:0034340 response to type I interferon(GO:0034340)
1.3 36.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.6 30.0 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.4 18.6 GO:0001919 regulation of receptor recycling(GO:0001919)
6.1 18.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
5.7 17.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
2.1 17.0 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
2.7 16.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
3.7 14.8 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.6 12.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 11.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
3.8 11.3 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
1.4 11.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
2.8 11.2 GO:0044565 dendritic cell proliferation(GO:0044565)
0.6 11.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
3.6 10.8 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
3.6 10.8 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
2.5 10.1 GO:0009597 detection of virus(GO:0009597)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 75.2 GO:0005634 nucleus(GO:0005634)
0.5 50.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 37.6 GO:0005739 mitochondrion(GO:0005739)
0.1 37.3 GO:0045177 apical part of cell(GO:0045177)
0.0 32.2 GO:0005730 nucleolus(GO:0005730)
0.6 27.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 21.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 19.1 GO:0005887 integral component of plasma membrane(GO:0005887)
1.2 18.6 GO:0043083 synaptic cleft(GO:0043083)
6.2 18.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 15.3 GO:0009986 cell surface(GO:0009986)
0.1 15.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 13.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.9 13.8 GO:0044754 autolysosome(GO:0044754)
0.1 12.8 GO:0005923 bicellular tight junction(GO:0005923)
0.3 12.5 GO:0016235 aggresome(GO:0016235)
0.1 11.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 10.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 9.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 8.9 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 91.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 50.7 GO:0019843 rRNA binding(GO:0019843)
1.2 27.5 GO:0005521 lamin binding(GO:0005521)
0.1 26.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.0 21.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 19.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
2.7 18.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 18.5 GO:0008083 growth factor activity(GO:0008083)
0.1 16.8 GO:0003924 GTPase activity(GO:0003924)
4.1 16.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 12.9 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.2 12.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 12.5 GO:0046332 SMAD binding(GO:0046332)
0.3 11.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 11.4 GO:0003727 single-stranded RNA binding(GO:0003727)
2.3 11.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
1.3 11.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
3.6 10.8 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
3.6 10.8 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 10.5 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 18.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 16.9 PID_SHP2_PATHWAY SHP2 signaling
0.2 16.6 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 11.9 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 10.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 10.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 8.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 7.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 7.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 6.4 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 6.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 6.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 5.2 PID_MYC_PATHWAY C-MYC pathway
0.2 5.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 4.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.5 4.5 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 4.1 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 3.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 3.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.4 SIG_CHEMOTAXIS Genes related to chemotaxis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 137.8 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
1.3 18.8 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.8 18.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 10.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 9.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.3 8.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 8.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 6.9 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.3 6.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 5.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 5.1 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.6 5.0 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.1 4.4 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 3.4 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 3.1 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.3 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.1 1.9 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 1.7 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.6 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 1.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism