Motif ID: Stat4_Stat3_Stat5b

Z-value: 0.993

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_51987139_51987151-0.612.2e-05Click!
Stat5bmm10_v2_chr11_-_100850724_100850763-0.462.8e-03Click!
Stat3mm10_v2_chr11_-_100939457_1009394840.296.6e-02Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 11.500 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr17_+_26715644 5.130 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chrX_-_61185558 5.099 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr4_-_64046925 4.209 ENSMUST00000107377.3
 Tnc
tenascin C
chr4_-_108031938 3.908 ENSMUST00000106708.1
 Podn
podocan
chr16_-_74411776 3.764 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr4_-_108032069 3.477 ENSMUST00000106709.2
 Podn
podocan
chr19_-_5797410 3.380 ENSMUST00000173314.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr1_+_34005872 3.266 ENSMUST00000182296.1
 Dst
dystonin
chr4_+_148602527 3.176 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr16_-_74411292 3.035 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr13_-_67755132 2.965 ENSMUST00000091520.6
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr5_+_88886809 2.921 ENSMUST00000148750.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr17_-_68004075 2.917 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr12_+_11265867 2.858 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr13_-_67755192 2.847 ENSMUST00000144183.1
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr16_-_23988852 2.842 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr7_-_78577771 2.820 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr5_-_34513892 2.819 ENSMUST00000114359.1
ENSMUST00000030991.7
ENSMUST00000087737.3
 Tnip2


TNFAIP3 interacting protein 2


chr2_+_3424123 2.736 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
 Dclre1c



DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 214 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.3 9.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.7 8.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.3 6.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 6.2 GO:0060612 adipose tissue development(GO:0060612)
1.0 5.1 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
1.1 4.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.6 4.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.7 3.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 3.1 GO:0034340 response to type I interferon(GO:0034340)
0.1 3.1 GO:0061157 positive regulation of mRNA catabolic process(GO:0061014) mRNA destabilization(GO:0061157)
0.7 2.9 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.6 2.9 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.3 2.9 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.2 2.9 GO:0015701 bicarbonate transport(GO:0015701)
0.9 2.8 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.9 2.8 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.3 2.7 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.6 2.6 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 2.6 GO:0045454 cell redox homeostasis(GO:0045454)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 11.5 GO:0032279 asymmetric synapse(GO:0032279)
0.0 9.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 7.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 6.8 GO:0030673 axolemma(GO:0030673)
0.0 5.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 3.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.8 3.3 GO:0031673 H zone(GO:0031673)
0.1 3.3 GO:0034451 centriolar satellite(GO:0034451)
0.5 3.2 GO:0005796 Golgi lumen(GO:0005796)
1.0 2.9 GO:0035061 interchromatin granule(GO:0035061)
0.2 2.7 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.2 2.6 GO:0044754 autolysosome(GO:0044754)
0.0 2.5 GO:0016605 PML body(GO:0016605)
0.6 2.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 2.4 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 2.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 2.2 GO:0030992 intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 11.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 7.9 GO:0030507 spectrin binding(GO:0030507)
0.8 6.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 5.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 5.8 GO:0005096 GTPase activator activity(GO:0005096)
1.0 4.9 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 4.9 GO:0005518 collagen binding(GO:0005518)
0.8 4.2 GO:0045545 syndecan binding(GO:0045545)
0.7 3.7 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 3.3 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)
0.2 3.0 GO:0001846 opsonin binding(GO:0001846)
0.1 3.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 2.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 2.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.6 2.8 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.3 2.7 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 2.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6 2.4 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 2.4 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.2 GO:0023026 MHC class II protein complex binding(GO:0023026)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.3 8.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.5 PID_IL2_1PATHWAY IL2-mediated signaling events
0.2 4.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.6 PID_SHP2_PATHWAY SHP2 signaling
0.3 3.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 3.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 3.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 2.9 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 1.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.6 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.2 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 1.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 11.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 8.2 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.2 8.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 6.4 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.6 3.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 3.5 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 3.1 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 3.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.9 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 2.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 2.0 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 1.9 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 1.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.8 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.0 1.7 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.6 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 1.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins