Motif ID: Stat5a
Z-value: 1.143
Transcription factors associated with Stat5a:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Stat5a | ENSMUSG00000004043.8 | Stat5a |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 424 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 8.4 | GO:0021764 | amygdala development(GO:0021764) |
| 0.3 | 5.8 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.2 | 5.8 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.9 | 5.2 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 1.6 | 4.9 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.2 | 4.8 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.2 | 4.7 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.9 | 4.4 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.1 | 4.4 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 1.1 | 4.3 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.1 | 4.2 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 1.4 | 4.1 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 1.3 | 3.9 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.4 | 3.9 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.9 | 3.7 | GO:0006014 | D-ribose metabolic process(GO:0006014) |
| 0.1 | 3.7 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 3.5 | 3.5 | GO:0070366 | regulation of hepatocyte differentiation(GO:0070366) |
| 0.1 | 3.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.8 | 3.1 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 0.0 | 3.0 | GO:0051028 | mRNA transport(GO:0051028) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 191 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 8.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 5.9 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 5.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 5.0 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 1.2 | 4.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 4.7 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 4.7 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.3 | 4.1 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 3.9 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.3 | 3.8 | GO:0043219 | lateral loop(GO:0043219) |
| 0.1 | 3.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 3.6 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.0 | 3.5 | GO:0005901 | caveola(GO:0005901) |
| 0.4 | 3.3 | GO:0005818 | aster(GO:0005818) |
| 0.0 | 3.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.4 | 3.1 | GO:0042627 | chylomicron(GO:0042627) |
| 0.2 | 3.1 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.4 | 2.7 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.7 | 2.6 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 282 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 8.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 6.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 5.9 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 1.7 | 5.2 | GO:0019958 | C-X-C chemokine binding(GO:0019958) |
| 0.2 | 5.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 4.8 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 4.4 | GO:0005507 | copper ion binding(GO:0005507) |
| 1.1 | 4.3 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.0 | 4.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 4.0 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 3.9 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.9 | 3.7 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.0 | 3.7 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 1.2 | 3.5 | GO:0044715 | 8-oxo-dGDP phosphatase activity(GO:0044715) |
| 1.2 | 3.5 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.1 | 3.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.4 | 3.3 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.3 | 3.3 | GO:0031404 | chloride ion binding(GO:0031404) |
| 1.0 | 3.1 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 62 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 7.1 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 6.7 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.1 | 6.5 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 6.1 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.3 | 5.9 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.1 | 5.9 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 5.9 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.5 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 5.1 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.3 | 4.1 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.7 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 3.2 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 3.2 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.2 | 3.1 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 2.9 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 2.9 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 2.8 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 2.6 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.3 | PID_E2F_PATHWAY | E2F transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 102 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 9.2 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 8.5 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 7.7 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 7.3 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 7.3 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 5.6 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.9 | REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.1 | 4.7 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 3.6 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.2 | 3.5 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 3.5 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 3.5 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.1 | 2.8 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.8 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 2.8 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.7 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.6 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 2.4 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 2.2 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
