Motif ID: Tbr1

Z-value: 0.910


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_61804538-0.297.1e-02Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_120899067 6.036 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr2_+_71528657 3.122 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr10_+_57784859 2.978 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr2_+_164562579 2.786 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr3_-_115715031 2.468 ENSMUST00000055676.2
 S1pr1
sphingosine-1-phosphate receptor 1
chr14_-_70642268 2.454 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr9_-_43239816 2.337 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr2_-_71546745 2.336 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr3_-_145649970 2.287 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr9_+_22454290 2.262 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr17_+_87635974 2.126 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr2_+_71529085 2.124 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr7_-_46672537 2.000 ENSMUST00000049298.7
 Tph1
tryptophan hydroxylase 1
chr7_-_116237767 1.898 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr8_+_45885479 1.838 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr10_+_57784914 1.832 ENSMUST00000165013.1
 Fabp7
fatty acid binding protein 7, brain
chr9_-_106199253 1.808 ENSMUST00000140761.1
 Ppm1m
protein phosphatase 1M
chr1_+_12692430 1.720 ENSMUST00000180062.1
ENSMUST00000177608.1
 Sulf1

sulfatase 1

chr12_+_85473883 1.659 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr9_-_21760275 1.645 ENSMUST00000098942.4
 Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 309 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 7.6 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.5 6.0 GO:0030091 protein repair(GO:0030091)
0.2 4.1 GO:0060134 prepulse inhibition(GO:0060134)
1.3 4.0 GO:0030421 defecation(GO:0030421)
0.6 3.7 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.7 2.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.5 2.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 2.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.8 2.5 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 2.4 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.1 2.2 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 2.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 2.0 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 2.0 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 2.0 GO:0051297 centrosome organization(GO:0051297)
0.3 1.9 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.5 1.8 GO:0032610 interleukin-1 alpha production(GO:0032610)
0.4 1.8 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 1.8 GO:0044243 multicellular organism catabolic process(GO:0044243)
0.6 1.7 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0016324 apical plasma membrane(GO:0016324)
0.0 5.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 4.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 4.1 GO:0005604 basement membrane(GO:0005604)
0.0 3.1 GO:0030027 lamellipodium(GO:0030027)
0.3 2.8 GO:0005915 zonula adherens(GO:0005915)
0.3 2.5 GO:0070652 HAUS complex(GO:0070652)
0.0 2.2 GO:0015934 large ribosomal subunit(GO:0015934)
0.5 2.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 2.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.4 2.0 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 2.0 GO:0005814 centriole(GO:0005814)
0.3 1.7 GO:0035976 AP1 complex(GO:0035976)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 1.6 GO:0031262 Ndc80 complex(GO:0031262)
0.3 1.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.6 GO:0042575 DNA polymerase complex(GO:0042575)
0.2 1.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 203 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 5.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 4.5 GO:0005504 fatty acid binding(GO:0005504)
0.1 3.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 3.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 3.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 3.0 GO:0008083 growth factor activity(GO:0008083)
0.0 3.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.6 2.8 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 2.8 GO:0070097 delta-catenin binding(GO:0070097)
0.2 2.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 2.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.8 2.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 2.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 2.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 2.4 GO:0008430 selenium binding(GO:0008430)
0.2 2.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.3 2.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 2.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.3 GO:0005520 insulin-like growth factor binding(GO:0005520)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 5.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 3.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 3.3 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.7 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 1.7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.3 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.0 PID_FANCONI_PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.5 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 2.5 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 2.1 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 2.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 2.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.9 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.1 1.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.8 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 1.7 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 1.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 1.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.4 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 1.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.3 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex