Motif ID: Tbx15

Z-value: 0.702


Transcription factors associated with Tbx15:

Gene SymbolEntrez IDGene Name
Tbx15 ENSMUSG00000027868.5 Tbx15



Activity profile for motif Tbx15.

activity profile for motif Tbx15


Sorted Z-values histogram for motif Tbx15

Sorted Z-values for motif Tbx15



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx15

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_48045144 7.702 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr6_+_108213086 3.983 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr17_-_81649607 3.640 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr19_-_10304867 3.452 ENSMUST00000039327.4
 Dagla
diacylglycerol lipase, alpha
chr12_-_78980758 3.089 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr4_-_129121889 2.907 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr16_-_23988852 2.655 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr16_-_43979050 2.422 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr11_+_83302817 2.411 ENSMUST00000142680.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr7_-_78577771 2.337 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr4_+_53440388 2.314 ENSMUST00000102911.3
ENSMUST00000107646.2
 Slc44a1

solute carrier family 44, member 1

chr7_-_78578308 2.311 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr5_+_32136458 2.296 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr14_-_30353468 2.263 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr7_-_24316590 2.197 ENSMUST00000108436.1
ENSMUST00000032673.8
 Zfp94

zinc finger protein 94

chr11_+_84179792 2.143 ENSMUST00000137500.2
ENSMUST00000130012.2
 Acaca

acetyl-Coenzyme A carboxylase alpha

chrX_+_41401128 2.108 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr8_-_8639363 2.065 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr11_+_83302641 2.061 ENSMUST00000176430.1
ENSMUST00000065692.7
 Ap2b1

adaptor-related protein complex 2, beta 1 subunit

chr7_-_132813715 2.055 ENSMUST00000134946.1
 Fam53b
family with sequence similarity 53, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 7.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.5 4.6 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.5 4.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
1.3 4.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.7 4.0 GO:0042045 epithelial fluid transport(GO:0042045)
0.0 3.7 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.7 3.6 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
1.2 3.5 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.7 3.5 GO:0015871 choline transport(GO:0015871)
0.1 3.4 GO:0001919 regulation of receptor recycling(GO:0001919)
1.1 3.3 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 2.8 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
1.3 2.7 GO:0032763 regulation of mast cell cytokine production(GO:0032763)
0.1 2.4 GO:0018345 protein palmitoylation(GO:0018345)
0.6 2.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 2.3 GO:0003334 keratinocyte development(GO:0003334)
0.5 2.1 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.3 2.1 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 2.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.7 2.0 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 GO:0030673 axolemma(GO:0030673)
0.0 5.5 GO:0043209 myelin sheath(GO:0043209)
0.1 5.1 GO:0030131 clathrin adaptor complex(GO:0030131)
1.3 4.0 GO:0031088 platelet dense granule membrane(GO:0031088)
0.3 4.0 GO:0044327 dendritic spine head(GO:0044327)
0.2 3.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 3.6 GO:0043198 dendritic shaft(GO:0043198)
0.2 3.5 GO:0043083 synaptic cleft(GO:0043083)
0.2 3.1 GO:0043196 varicosity(GO:0043196)
0.4 2.8 GO:0071203 WASH complex(GO:0071203)
0.0 2.7 GO:0043197 dendritic spine(GO:0043197)
0.0 2.7 GO:0043235 receptor complex(GO:0043235)
0.2 2.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 2.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 1.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.8 GO:0030139 endocytic vesicle(GO:0030139)
0.1 1.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 1.6 GO:0030314 junctional membrane complex(GO:0030314)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 4.9 GO:0030275 LRR domain binding(GO:0030275)
0.9 4.6 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.6 4.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 4.5 GO:0030276 clathrin binding(GO:0030276)
1.3 4.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.9 3.5 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.9 3.5 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.2 3.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.5 2.9 GO:0097001 ceramide binding(GO:0097001)
0.1 2.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 2.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 2.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 2.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.3 2.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.7 2.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 2.0 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.0 2.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6 1.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 1.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 4.4 PID_SHP2_PATHWAY SHP2 signaling
0.1 3.6 PID_FGF_PATHWAY FGF signaling pathway
0.1 3.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.3 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 2.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID_FOXO_PATHWAY FoxO family signaling
0.1 2.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 1.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.3 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 5.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 4.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.3 3.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 3.5 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 3.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.1 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 2.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.9 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 1.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.2 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.0 REACTOME_KINESINS Genes involved in Kinesins