Motif ID: Tbx19

Z-value: 0.638


Transcription factors associated with Tbx19:

Gene SymbolEntrez IDGene Name
Tbx19 ENSMUSG00000026572.5 Tbx19



Activity profile for motif Tbx19.

activity profile for motif Tbx19


Sorted Z-values histogram for motif Tbx19

Sorted Z-values for motif Tbx19



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx19

PNG image of the network

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Top targets:


Showing 1 to 20 of 106 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_130936172 3.027 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr2_-_113758638 2.930 ENSMUST00000099575.3
 Grem1
gremlin 1
chr3_+_94693556 2.246 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr18_-_82406777 2.199 ENSMUST00000065224.6
 Galr1
galanin receptor 1
chr19_+_5474681 2.115 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
 Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr6_+_90465287 1.726 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chrY_+_897782 1.587 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr14_+_115042752 1.539 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr2_+_179442427 1.415 ENSMUST00000000314.6
 Cdh4
cadherin 4
chr3_-_97610156 1.399 ENSMUST00000029730.4
 Chd1l
chromodomain helicase DNA binding protein 1-like
chr10_-_86011833 1.267 ENSMUST00000105304.1
ENSMUST00000061699.5
 Bpifc

BPI fold containing family C

chr5_-_92278155 1.237 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr17_+_6978860 1.226 ENSMUST00000089119.5
ENSMUST00000179728.1
 Rnaset2b

ribonuclease T2B

chr11_-_60046477 1.184 ENSMUST00000000310.7
ENSMUST00000102693.2
ENSMUST00000148512.1
 Pemt


phosphatidylethanolamine N-methyltransferase


chr14_-_66124482 1.172 ENSMUST00000070515.1
 Ephx2
epoxide hydrolase 2, cytoplasmic
chr7_+_48959089 1.144 ENSMUST00000183659.1
 Nav2
neuron navigator 2
chr6_-_119467210 1.104 ENSMUST00000118120.1
 Wnt5b
wingless-related MMTV integration site 5B
chr5_-_115484297 1.033 ENSMUST00000112067.1
 Sirt4
sirtuin 4
chr2_+_175010241 0.890 ENSMUST00000109069.1
ENSMUST00000109070.2
 Gm14444

predicted gene 14444

chr6_+_17749170 0.886 ENSMUST00000053148.7
ENSMUST00000115417.3
 St7

suppression of tumorigenicity 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.0 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.0 2.9 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
0.6 1.9 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.1 1.7 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.3 1.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.2 1.4 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 1.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.4 1.2 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.0 1.2 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 1.1 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.0 1.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.2 1.0 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 0.7 GO:0098734 protein depalmitoylation(GO:0002084) positive regulation of pinocytosis(GO:0048549) macromolecule depalmitoylation(GO:0098734)
0.1 0.7 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.0 0.7 GO:0032402 melanosome transport(GO:0032402)
0.0 0.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.7 GO:0035411 catenin import into nucleus(GO:0035411)
0.1 0.6 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.1 0.6 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.2 0.5 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.0 1.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.5 GO:0000802 transverse filament(GO:0000802)
0.2 0.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.5 GO:0005785 signal recognition particle receptor complex(GO:0005785) dense body(GO:0097433)
0.1 0.4 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.4 GO:0097361 CIA complex(GO:0097361)
0.1 0.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.3 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 0.3 GO:0033093 multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093)
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 2.9 GO:0036122 BMP binding(GO:0036122)
0.2 2.2 GO:0008430 selenium binding(GO:0008430)
0.5 1.9 GO:0004966 galanin receptor activity(GO:0004966)
0.2 1.6 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 1.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 1.2 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 1.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 1.2 GO:0004540 ribonuclease activity(GO:0004540)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.1 1.0 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.7 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.7 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 0.7 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.7 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.1 0.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 0.5 GO:0032139 DNA polymerase processivity factor activity(GO:0030337) dinucleotide insertion or deletion binding(GO:0032139)
0.1 0.5 GO:0015091 signal recognition particle binding(GO:0005047) ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway