Motif ID: Tbx1_Eomes

Z-value: 0.914

Transcription factors associated with Tbx1_Eomes:

Gene SymbolEntrez IDGene Name
Eomes ENSMUSG00000032446.8 Eomes
Tbx1 ENSMUSG00000009097.9 Tbx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomesmm10_v2_chr9_+_118478182_118478212-0.305.6e-02Click!


Activity profile for motif Tbx1_Eomes.

activity profile for motif Tbx1_Eomes


Sorted Z-values histogram for motif Tbx1_Eomes

Sorted Z-values for motif Tbx1_Eomes



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx1_Eomes

PNG image of the network

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Top targets:


Showing 1 to 20 of 154 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 19.624 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr2_-_13011747 11.966 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr1_+_6730051 10.175 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr4_+_125490688 9.593 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr1_-_138847579 9.254 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr2_-_57114970 7.911 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr9_-_43239816 7.543 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr1_+_6730135 6.596 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr17_+_29093763 6.283 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_+_164562579 6.172 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr6_-_94700137 5.784 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr7_-_28302238 5.031 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr1_+_132316112 4.893 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr4_-_35845204 4.886 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr12_+_3891728 4.660 ENSMUST00000172689.1
ENSMUST00000111186.1
 Dnmt3a

DNA methyltransferase 3A

chr6_+_7555053 3.981 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr10_-_92162753 3.839 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr10_-_120899067 3.797 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr6_+_15196949 3.756 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chrX_+_142681398 3.746 ENSMUST00000112889.1
ENSMUST00000101198.2
ENSMUST00000112891.1
ENSMUST00000087333.2
 Tmem164



transmembrane protein 164




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 16.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 16.4 GO:0050807 regulation of synapse organization(GO:0050807)
0.8 11.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.9 9.6 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.9 9.3 GO:0035262 gonad morphogenesis(GO:0035262)
2.0 7.9 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 6.4 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.7 6.3 GO:0071493 cellular response to UV-B(GO:0071493)
1.9 5.8 GO:0032474 otolith morphogenesis(GO:0032474)
0.6 5.3 GO:0090527 actin filament reorganization(GO:0090527)
1.0 5.0 GO:0007386 compartment pattern specification(GO:0007386)
0.1 4.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.6 4.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
2.0 4.0 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.9 3.8 GO:0030091 protein repair(GO:0030091)
0.3 3.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.8 3.2 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.1 3.1 GO:0007340 acrosome reaction(GO:0007340)
1.0 2.9 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.3 2.9 GO:0010587 miRNA catabolic process(GO:0010587)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.9 GO:0032993 protein-DNA complex(GO:0032993)
0.2 12.4 GO:0005581 collagen trimer(GO:0005581)
0.3 11.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 9.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 6.4 GO:0016607 nuclear speck(GO:0016607)
2.1 6.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 5.3 GO:0005884 actin filament(GO:0005884)
0.2 4.7 GO:0001741 XY body(GO:0001741)
0.5 3.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 3.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.9 2.8 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.3 2.8 GO:0005916 fascia adherens(GO:0005916)
0.0 2.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 1.6 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 1.4 GO:1990357 terminal web(GO:1990357)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 1.3 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.9 9.6 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 8.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 6.4 GO:0001047 core promoter binding(GO:0001047)
2.1 6.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.2 6.2 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.7 5.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 5.0 GO:0005112 Notch binding(GO:0005112)
0.6 4.7 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 4.4 GO:0000287 magnesium ion binding(GO:0000287)
0.6 3.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 3.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
1.1 3.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.7 2.9 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.3 2.9 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.2 2.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 2.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 2.4 GO:0008432 JUN kinase binding(GO:0008432)
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 2.0 GO:0050501 hyaluronan synthase activity(GO:0050501)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7 6.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 6.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 5.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 2.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.5 9.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 6.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 4.1 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 4.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 3.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 2.9 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 2.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 2.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.4 1.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP