Motif ID: Tbx2

Z-value: 0.461


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.241.3e-01Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 120 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 4.066 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_138847579 3.474 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr7_-_137314394 1.424 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr14_+_68083853 1.312 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr15_+_61987034 1.160 ENSMUST00000159338.1
 Myc
myelocytomatosis oncogene
chr1_-_105356658 1.060 ENSMUST00000058688.5
ENSMUST00000172299.1
 Rnf152

ring finger protein 152

chr1_+_132316112 0.988 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr2_+_124089961 0.967 ENSMUST00000103241.1
 Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr1_-_172329261 0.905 ENSMUST00000062387.2
 Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr18_-_62741387 0.881 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr5_+_108065742 0.787 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
 Mtf2


metal response element binding transcription factor 2


chr1_-_52500679 0.771 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr3_-_158562199 0.752 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chr3_+_102734496 0.733 ENSMUST00000029451.5
 Tspan2
tetraspanin 2
chr4_+_116221633 0.675 ENSMUST00000030464.7
 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr11_-_84068766 0.626 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr5_+_108065696 0.613 ENSMUST00000172045.1
 Mtf2
metal response element binding transcription factor 2
chr3_-_127499095 0.603 ENSMUST00000182594.1
 Ank2
ankyrin 2, brain
chr10_+_96136603 0.599 ENSMUST00000074615.6
 Gm5426
predicted pseudogene 5426
chr6_+_15196949 0.589 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.5 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 1.4 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 1.4 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.4 1.3 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.3 1.2 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.0 1.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.0 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.2 0.9 GO:0060467 negative regulation of fertilization(GO:0060467)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 0.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.8 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 0.7 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.2 0.6 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.1 0.6 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.5 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.5 GO:0046543 development of secondary female sexual characteristics(GO:0046543)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 1.3 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 1.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.0 0.8 GO:0043194 axon initial segment(GO:0043194)
0.0 0.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.5 GO:0071565 nBAF complex(GO:0071565)
0.1 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.1 0.2 GO:0002141 stereocilia ankle link(GO:0002141)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.7 GO:0070888 E-box binding(GO:0070888)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.3 GO:0043274 phospholipase binding(GO:0043274)
0.1 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.3 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 1.2 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.3 PID_BCR_5PATHWAY BCR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.1 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.1 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR