Motif ID: Tbx21
Z-value: 0.951
Transcription factors associated with Tbx21:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tbx21 | ENSMUSG00000001444.2 | Tbx21 |
Top targets:
Showing 1 to 20 of 145 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 65 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.8 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.5 | 8.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.8 | 4.5 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.1 | 4.4 | GO:0060113 | inner ear receptor cell differentiation(GO:0060113) |
| 0.4 | 3.7 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 3.4 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 1.0 | 3.0 | GO:0021649 | vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835) |
| 0.0 | 2.9 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.7 | 2.8 | GO:0010040 | response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468) |
| 0.4 | 2.7 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.1 | 2.6 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.1 | 2.6 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.2 | 2.4 | GO:0021540 | corpus callosum morphogenesis(GO:0021540) corticospinal tract morphogenesis(GO:0021957) |
| 0.3 | 2.3 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.0 | 2.3 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 2.2 | GO:0008202 | steroid metabolic process(GO:0008202) |
| 0.5 | 2.0 | GO:1903860 | negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) |
| 0.6 | 1.9 | GO:0043379 | rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 0.4 | 1.8 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.2 | 1.8 | GO:0051014 | actin filament severing(GO:0051014) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 35 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 3.7 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 3.4 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 3.3 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.2 | 3.2 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.7 | 2.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 2.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 2.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 2.3 | GO:0031430 | M band(GO:0031430) |
| 0.6 | 1.9 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.0 | 1.9 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.2 | 1.7 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.3 | 1.6 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.1 | 1.4 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 1.3 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 1.3 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.2 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 1.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 1.2 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 1.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 55 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.3 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.0 | 7.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 7.2 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.2 | 3.7 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.2 | 3.7 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.5 | 3.2 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.4 | 3.0 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.5 | 2.8 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.1 | 2.7 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.2 | 2.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 2.6 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.0 | 2.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 2.4 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.1 | 2.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 2.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 2.2 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 2.0 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.3 | 1.9 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 1.9 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in C2:CP category:
Showing 1 to 16 of 16 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.2 | 3.0 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 2.9 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 2.8 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 2.7 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.2 | 2.6 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 2.6 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 2.6 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.9 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 1.2 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 1.2 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.1 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.1 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.7 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.3 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.3 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 25 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 3.0 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 2.9 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 2.7 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.5 | 2.6 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 2.3 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 2.2 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.9 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 1.8 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 1.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 1.7 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 1.3 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.2 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 1.1 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 1.0 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.8 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.8 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.8 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 0.7 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.6 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
