Motif ID: Tcf21_Msc
Z-value: 1.166
Transcription factors associated with Tcf21_Msc:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Msc | ENSMUSG00000025930.5 | Msc |
| Tcf21 | ENSMUSG00000045680.7 | Tcf21 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 203 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 16.1 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.1 | 7.7 | GO:0051592 | response to calcium ion(GO:0051592) |
| 1.2 | 6.1 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) positive regulation of NAD(P)H oxidase activity(GO:0033864) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) |
| 1.3 | 5.1 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 1.0 | 5.0 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 0.8 | 4.7 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.7 | 4.4 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.4 | 4.3 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 1.4 | 4.1 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 1.3 | 4.0 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
| 0.3 | 3.8 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.2 | 3.8 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 3.7 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.1 | 3.7 | GO:0048663 | neuron fate commitment(GO:0048663) |
| 1.1 | 3.2 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.3 | 3.2 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.1 | 3.2 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 3.1 | GO:0007569 | cell aging(GO:0007569) |
| 0.3 | 2.9 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.1 | 2.7 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 89 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 11.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 7.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.2 | 6.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 5.2 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 5.1 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 4.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 4.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 4.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.8 | 3.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 3.3 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 2.8 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 2.6 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 2.5 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.2 | 2.4 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 2.4 | GO:0005605 | basal lamina(GO:0005605) |
| 0.2 | 1.9 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.2 | 1.8 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 1.8 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 1.8 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 139 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 16.1 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.0 | 9.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 1.5 | 6.1 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 6.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 5.4 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 5.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.8 | 5.0 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 0.2 | 4.7 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.6 | 4.4 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.3 | 4.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 3.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.5 | 3.2 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.0 | 3.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 3.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.4 | 3.1 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.2 | 3.1 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.1 | 3.1 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 3.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 2.7 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.4 | 2.6 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 41 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 5.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.1 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.3 | 5.0 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 4.5 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 4.1 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 3.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.7 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.2 | 2.6 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.3 | 2.4 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 2.2 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 1.9 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.7 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 1.7 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 1.6 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.3 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.2 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 1.2 | NABA_MATRISOME_ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 50 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 6.1 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 5.6 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 5.1 | REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 4.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.6 | 4.3 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.2 | 3.8 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 3.2 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 2.7 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 2.2 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 2.1 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 2.1 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.7 | REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.2 | 1.6 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 1.6 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 1.5 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 1.4 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.2 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 1.1 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
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