Motif ID: Tcf3

Z-value: 0.655


Transcription factors associated with Tcf3:

Gene SymbolEntrez IDGene Name
Tcf3 ENSMUSG00000020167.8 Tcf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf3mm10_v2_chr10_-_80433615_804336550.525.7e-04Click!


Activity profile for motif Tcf3.

activity profile for motif Tcf3


Sorted Z-values histogram for motif Tcf3

Sorted Z-values for motif Tcf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_28302238 4.317 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr14_-_20181773 3.398 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr12_+_109459843 3.386 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr6_-_72235559 3.158 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr13_-_60177357 3.026 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr15_+_34238026 2.921 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr13_-_116309639 2.528 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr1_+_74791516 2.429 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr5_-_98566762 2.409 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr6_+_17307632 2.254 ENSMUST00000115453.1
 Cav1
caveolin 1, caveolae protein
chr6_+_17307272 2.212 ENSMUST00000115454.1
 Cav1
caveolin 1, caveolae protein
chr7_+_19094594 2.159 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr8_-_122699066 1.966 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr15_-_98004634 1.938 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr14_+_27039001 1.922 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr19_+_25610533 1.920 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr15_-_98004695 1.913 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr2_+_131186942 1.857 ENSMUST00000028804.8
ENSMUST00000079857.8
 Cdc25b

cell division cycle 25B

chr7_-_17056669 1.811 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chrX_-_106485214 1.755 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 4.5 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.9 4.3 GO:0007386 compartment pattern specification(GO:0007386)
0.4 4.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.4 4.1 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.4 4.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 3.5 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 3.4 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 3.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.3 3.2 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.2 3.1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1 3.1 GO:0035329 hippo signaling(GO:0035329)
0.5 2.7 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.8 2.5 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.2 2.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.8 2.3 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.2 2.2 GO:0014841 skeletal muscle satellite cell proliferation(GO:0014841)
0.3 2.0 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.3 1.9 GO:0007144 female meiosis I(GO:0007144)
0.0 1.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.4 1.7 GO:0061743 motor learning(GO:0061743)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 4.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 3.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 3.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 3.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 3.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.5 GO:0000922 spindle pole(GO:0000922)
0.1 2.4 GO:0001891 phagocytic cup(GO:0001891)
0.5 2.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.9 GO:0005819 spindle(GO:0005819)
0.0 1.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.6 1.7 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.3 1.7 GO:0097149 centralspindlin complex(GO:0097149)
0.2 1.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.6 GO:0031970 organelle envelope lumen(GO:0031970)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.5 GO:0097542 ciliary tip(GO:0097542)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 5.0 GO:0070888 E-box binding(GO:0070888)
0.1 4.7 GO:0005112 Notch binding(GO:0005112)
0.9 4.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.4 4.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 4.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.8 3.9 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 3.6 GO:0002039 p53 binding(GO:0002039)
0.2 3.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 3.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 3.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 2.8 GO:0005109 frizzled binding(GO:0005109)
0.4 2.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 2.5 GO:0003774 motor activity(GO:0003774)
0.3 2.4 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.3 GO:0051861 glycolipid binding(GO:0051861)
0.6 1.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.7 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 4.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 3.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.1 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 1.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.7 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.5 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 1.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_BARD1_PATHWAY BARD1 signaling events
0.1 1.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 4.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 3.8 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0 3.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 3.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 3.3 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 3.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.6 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 2.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 2.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.5 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.4 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 1.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors