Motif ID: Tcf4_Mesp1

Z-value: 2.193

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69346143_693462030.444.2e-03Click!


Activity profile for motif Tcf4_Mesp1.

activity profile for motif Tcf4_Mesp1


Sorted Z-values histogram for motif Tcf4_Mesp1

Sorted Z-values for motif Tcf4_Mesp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_57907587 22.013 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr15_-_66831625 17.107 ENSMUST00000164163.1
 Sla
src-like adaptor
chr5_-_139130159 12.017 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_+_37028329 11.626 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr16_-_97170707 10.947 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr2_-_121806988 10.872 ENSMUST00000110592.1
 Frmd5
FERM domain containing 5
chr12_+_82616885 10.757 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr7_+_121707189 10.434 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr5_+_117413977 9.798 ENSMUST00000180430.1
 Ksr2
kinase suppressor of ras 2
chr12_+_102948843 9.749 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chrX_+_159627265 9.539 ENSMUST00000112456.2
 Sh3kbp1
SH3-domain kinase binding protein 1
chr3_+_75557530 9.504 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr8_+_12873793 9.433 ENSMUST00000156560.1
ENSMUST00000095456.3
 Mcf2l

mcf.2 transforming sequence-like

chr12_-_79007276 9.283 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr1_-_158356258 9.064 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr2_-_33371400 8.865 ENSMUST00000113164.1
ENSMUST00000091039.2
ENSMUST00000042615.6
 Ralgps1


Ral GEF with PH domain and SH3 binding motif 1


chr8_-_4217133 8.771 ENSMUST00000175906.1
 BC068157
cDNA sequence BC068157
chr14_+_101729907 8.552 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr14_-_30353468 8.242 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr11_+_42419729 8.157 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 618 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 25.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
2.1 21.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.7 19.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.3 19.0 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.2 17.6 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
1.1 16.9 GO:0048194 Golgi vesicle budding(GO:0048194)
1.6 15.9 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.4 15.1 GO:0008333 endosome to lysosome transport(GO:0008333)
1.2 15.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.4 14.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.7 14.3 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
1.1 12.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 12.1 GO:0031032 actomyosin structure organization(GO:0031032)
1.5 11.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.7 11.9 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.7 11.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.3 11.4 GO:0071420 cellular response to histamine(GO:0071420)
1.1 11.3 GO:0046959 habituation(GO:0046959)
0.2 11.2 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.9 11.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 223 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 60.3 GO:0060076 excitatory synapse(GO:0060076)
0.4 51.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 33.4 GO:0005802 trans-Golgi network(GO:0005802)
0.4 27.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.9 26.6 GO:0033268 node of Ranvier(GO:0033268)
0.4 23.5 GO:0031985 Golgi cisterna(GO:0031985)
0.6 19.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 18.3 GO:0031901 early endosome membrane(GO:0031901)
0.8 17.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.0 13.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.9 13.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 13.0 GO:0097060 synaptic membrane(GO:0097060)
0.1 12.7 GO:0005769 early endosome(GO:0005769)
0.0 12.3 GO:0005794 Golgi apparatus(GO:0005794)
0.6 11.0 GO:0032279 asymmetric synapse(GO:0032279)
0.3 11.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 10.4 GO:0042734 presynaptic membrane(GO:0042734)
0.2 10.2 GO:0031594 neuromuscular junction(GO:0031594)
0.2 10.2 GO:0030139 endocytic vesicle(GO:0030139)
2.4 9.5 GO:0031983 vesicle lumen(GO:0031983)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 383 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 35.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 33.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.6 25.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.7 21.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.6 20.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.1 19.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
1.6 19.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.0 17.8 GO:0050811 GABA receptor binding(GO:0050811)
1.5 16.8 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.3 16.3 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
1.8 15.9 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.3 14.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.5 13.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 13.8 GO:0030507 spectrin binding(GO:0030507)
0.7 13.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.6 13.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.3 12.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 12.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.6 12.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 12.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 34.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.6 28.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.3 27.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 18.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.5 16.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 16.4 PID_LKB1_PATHWAY LKB1 signaling events
0.2 14.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.4 14.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 12.9 PID_P73PATHWAY p73 transcription factor network
0.3 12.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.3 11.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.3 11.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 11.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.3 11.0 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.3 10.0 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.2 7.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 7.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4 7.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 7.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.3 7.4 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 22.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 17.2 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.4 16.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 16.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.7 16.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.9 14.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.4 13.7 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.8 13.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 13.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.5 10.8 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.7 10.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.7 10.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.4 10.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.3 9.4 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 9.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.7 8.8 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 8.5 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 8.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.6 7.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.6 7.6 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events