Motif ID: Tcf7_Tcf7l2
Z-value: 0.986


Transcription factors associated with Tcf7_Tcf7l2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Tcf7 | ENSMUSG00000000782.9 | Tcf7 |
Tcf7l2 | ENSMUSG00000024985.12 | Tcf7l2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Tcf7 | mm10_v2_chr11_-_52282564_52282579 | -0.43 | 5.2e-03 | Click! |
Tcf7l2 | mm10_v2_chr19_+_55894508_55894534 | 0.28 | 8.1e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 142 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 5.3 | GO:0006275 | regulation of DNA replication(GO:0006275) |
0.6 | 4.3 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
0.4 | 4.1 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.0 | 3.6 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
0.1 | 2.5 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
0.0 | 2.5 | GO:0007411 | axon guidance(GO:0007411) |
0.0 | 2.3 | GO:2001222 | regulation of neuron migration(GO:2001222) |
0.0 | 2.0 | GO:0001947 | heart looping(GO:0001947) |
0.5 | 1.9 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
0.6 | 1.7 | GO:0019389 | glucuronoside metabolic process(GO:0019389) |
0.3 | 1.6 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
0.0 | 1.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 1.6 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
0.5 | 1.5 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
0.0 | 1.4 | GO:0007032 | endosome organization(GO:0007032) |
0.1 | 1.3 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
0.1 | 1.2 | GO:2000303 | regulation of ceramide biosynthetic process(GO:2000303) |
0.1 | 1.1 | GO:0035372 | protein localization to microtubule(GO:0035372) |
0.0 | 1.1 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
0.1 | 1.0 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 57 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 6.6 | GO:0072562 | blood microparticle(GO:0072562) |
0.1 | 4.3 | GO:0030673 | axolemma(GO:0030673) |
0.2 | 4.1 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.0 | 2.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.1 | 1.9 | GO:0005640 | nuclear outer membrane(GO:0005640) |
0.1 | 1.9 | GO:0045120 | pronucleus(GO:0045120) |
0.1 | 1.6 | GO:0010369 | chromocenter(GO:0010369) |
0.3 | 1.3 | GO:0005594 | collagen type IX trimer(GO:0005594) |
0.0 | 1.2 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 1.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
0.3 | 1.1 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
0.3 | 1.0 | GO:0044307 | dendritic branch(GO:0044307) |
0.1 | 1.0 | GO:0001739 | sex chromatin(GO:0001739) |
0.1 | 1.0 | GO:0031932 | TORC2 complex(GO:0031932) |
0.1 | 0.9 | GO:0070695 | FHF complex(GO:0070695) |
0.1 | 0.9 | GO:0033269 | internode region of axon(GO:0033269) |
0.1 | 0.9 | GO:0030478 | actin cap(GO:0030478) |
0.0 | 0.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.8 | GO:0016580 | Sin3 complex(GO:0016580) |
0.0 | 0.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 100 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 6.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.7 | 4.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.1 | 4.1 | GO:0030507 | spectrin binding(GO:0030507) |
0.4 | 2.5 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
0.2 | 2.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.0 | 2.2 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
0.1 | 1.9 | GO:0043495 | protein anchor(GO:0043495) |
0.5 | 1.6 | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
0.2 | 1.2 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
0.0 | 1.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.3 | 1.1 | GO:0051377 | mannose-ethanolamine phosphotransferase activity(GO:0051377) |
0.0 | 1.1 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
0.1 | 1.0 | GO:0038191 | neuropilin binding(GO:0038191) |
0.0 | 1.0 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
0.0 | 1.0 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
0.0 | 1.0 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
0.0 | 1.0 | GO:0043022 | ribosome binding(GO:0043022) |
0.2 | 0.9 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.0 | 0.9 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.0 | 0.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 21 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 2.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.1 | 2.5 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 1.8 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
0.0 | 1.5 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
0.0 | 1.4 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 1.3 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.1 | 1.1 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
0.0 | 1.0 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
0.0 | 1.0 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
0.1 | 0.7 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
0.0 | 0.7 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
0.0 | 0.7 | PID_PTP1B_PATHWAY | Signaling events mediated by PTP1B |
0.0 | 0.6 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
0.0 | 0.6 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
0.0 | 0.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 0.5 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 0.5 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.1 | 0.4 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
0.0 | 0.4 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
0.0 | 0.4 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 48 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.6 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.1 | 3.9 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.1 | 2.9 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.1 | 2.5 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.0 | 1.6 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 1.5 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
0.0 | 1.3 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.0 | 1.3 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
0.2 | 1.1 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.0 | 1.1 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
0.1 | 1.0 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
0.0 | 1.0 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
0.0 | 1.0 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.1 | 0.9 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PC | Genes involved in Acyl chain remodelling of PC |
0.0 | 0.9 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.0 | 0.9 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 0.9 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
0.0 | 0.8 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
0.0 | 0.8 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.0 | 0.8 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |