Motif ID: Tcf7_Tcf7l2

Z-value: 0.986

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7mm10_v2_chr11_-_52282564_52282579-0.435.2e-03Click!
Tcf7l2mm10_v2_chr19_+_55894508_558945340.288.1e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_102706356 4.283 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr9_-_96719549 3.362 ENSMUST00000128269.1
Zbtb38
zinc finger and BTB domain containing 38
chr2_+_153031852 3.113 ENSMUST00000037235.6
Xkr7
X Kell blood group precursor related family member 7 homolog
chr10_-_116972609 2.879 ENSMUST00000092165.4
Gm10271
predicted gene 10271
chr2_+_152081529 2.293 ENSMUST00000064061.3
Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr12_-_41485751 2.118 ENSMUST00000043884.4
Lrrn3
leucine rich repeat protein 3, neuronal
chr3_+_76074270 1.972 ENSMUST00000038364.8
Fstl5
follistatin-like 5
chr12_+_52699297 1.884 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr9_-_96719404 1.877 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr16_-_45742888 1.742 ENSMUST00000128348.1
ENSMUST00000066983.6
Abhd10

abhydrolase domain containing 10

chrX_+_101532734 1.616 ENSMUST00000118878.1
ENSMUST00000101341.2
ENSMUST00000149274.1
Taf1


TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor


chr10_-_92165159 1.563 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr17_+_21690766 1.558 ENSMUST00000097384.1
Gm10509
predicted gene 10509
chr5_+_90759299 1.483 ENSMUST00000031318.4
Cxcl5
chemokine (C-X-C motif) ligand 5
chr4_+_121039385 1.469 ENSMUST00000030372.5
Col9a2
collagen, type IX, alpha 2
chr2_-_38926217 1.381 ENSMUST00000076275.4
ENSMUST00000142130.1
Nr6a1

nuclear receptor subfamily 6, group A, member 1

chr17_+_43952999 1.372 ENSMUST00000177857.1
Rcan2
regulator of calcineurin 2
chr4_-_91376433 1.364 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr18_+_10725651 1.363 ENSMUST00000165555.1
Mib1
mindbomb homolog 1 (Drosophila)
chr1_-_64121389 1.325 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0006275 regulation of DNA replication(GO:0006275)
0.6 4.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.4 4.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 3.6 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 2.5 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 2.5 GO:0007411 axon guidance(GO:0007411)
0.0 2.3 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 2.0 GO:0001947 heart looping(GO:0001947)
0.5 1.9 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.6 1.7 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.3 1.6 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 1.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.5 1.5 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.0 1.4 GO:0007032 endosome organization(GO:0007032)
0.1 1.3 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 1.2 GO:2000303 regulation of ceramide biosynthetic process(GO:2000303)
0.1 1.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 1.1 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.0 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 GO:0072562 blood microparticle(GO:0072562)
0.1 4.3 GO:0030673 axolemma(GO:0030673)
0.2 4.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 1.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.9 GO:0045120 pronucleus(GO:0045120)
0.1 1.6 GO:0010369 chromocenter(GO:0010369)
0.3 1.3 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.3 1.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.3 1.0 GO:0044307 dendritic branch(GO:0044307)
0.1 1.0 GO:0001739 sex chromatin(GO:0001739)
0.1 1.0 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.9 GO:0070695 FHF complex(GO:0070695)
0.1 0.9 GO:0033269 internode region of axon(GO:0033269)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.0 0.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.8 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.7 4.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 4.1 GO:0030507 spectrin binding(GO:0030507)
0.4 2.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 2.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 2.2 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 1.9 GO:0043495 protein anchor(GO:0043495)
0.5 1.6 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.2 1.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 1.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 1.1 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.2 0.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.9 GO:0008536 Ran GTPase binding(GO:0008536)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.8 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 1.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 0.7 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.7 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.6 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 0.4 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.5 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 1.1 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.1 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.0 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.8 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA