Motif ID: Tcf7l1

Z-value: 0.913


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.391.2e-02Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_108921648 4.471 ENSMUST00000144511.1
 Axin2
axin2
chr11_+_108920800 4.405 ENSMUST00000140821.1
 Axin2
axin2
chr3_+_131110350 3.317 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr14_+_27039001 3.121 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr2_+_153031852 2.663 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr1_-_183147461 2.600 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr9_+_85842852 2.482 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr9_+_35423582 2.353 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr14_-_98169542 2.300 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr17_-_70851189 2.253 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_115824699 2.244 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr2_+_70474923 2.221 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr15_+_34238026 2.166 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr7_+_45216671 2.084 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr4_+_62583568 2.052 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr13_-_102906046 2.008 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr5_-_148392810 1.990 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr13_-_102905740 1.868 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr7_+_100493795 1.848 ENSMUST00000129324.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr18_-_62756275 1.801 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 10.0 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 3.9 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
1.1 3.3 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.5 3.0 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.2 2.9 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.5 2.8 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 2.6 GO:0060539 diaphragm development(GO:0060539)
0.3 2.4 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.3 2.4 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.8 2.3 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 2.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 2.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 2.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 2.2 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.2 2.1 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 2.0 GO:0015809 arginine transport(GO:0015809)
0.5 1.9 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 1.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 1.8 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 1.8 GO:0009409 response to cold(GO:0009409)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.9 GO:0005813 centrosome(GO:0005813)
0.3 3.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 2.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.7 2.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 1.9 GO:0071564 npBAF complex(GO:0071564)
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.6 GO:0000922 spindle pole(GO:0000922)
0.1 1.5 GO:0001739 sex chromatin(GO:0001739)
0.1 1.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.4 GO:0036038 MKS complex(GO:0036038)
0.0 1.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 1.3 GO:0001533 cornified envelope(GO:0001533)
0.1 1.3 GO:0044294 dendritic growth cone(GO:0044294)
0.3 1.2 GO:0008623 CHRAC(GO:0008623)
0.1 1.2 GO:0016342 catenin complex(GO:0016342)
0.4 1.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.3 1.1 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 10.0 GO:0070411 I-SMAD binding(GO:0070411)
0.0 6.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.4 GO:0005096 GTPase activator activity(GO:0005096)
0.6 3.3 GO:0030284 estrogen receptor activity(GO:0030284)
1.0 3.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 2.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 2.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 2.5 GO:0015197 peptide transporter activity(GO:0015197)
0.0 2.5 GO:0000287 magnesium ion binding(GO:0000287)
0.1 2.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 2.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 2.3 GO:0070410 co-SMAD binding(GO:0070410)
0.2 2.0 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 1.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 1.8 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.5 1.8 GO:0050436 microfibril binding(GO:0050436)
0.2 1.7 GO:0034711 inhibin binding(GO:0034711)
0.1 1.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 1.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 6.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 2.6 PID_FGF_PATHWAY FGF signaling pathway
0.0 2.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.7 PID_ALK1_PATHWAY ALK1 signaling events
0.1 1.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 1.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 PID_MYC_PATHWAY C-MYC pathway
0.0 0.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 3.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 3.2 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR
0.0 3.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 1.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 1.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.8 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.8 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 0.7 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.7 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.1 0.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.5 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters