Motif ID: Tead3_Tead4

Z-value: 2.789

Transcription factors associated with Tead3_Tead4:

Gene SymbolEntrez IDGene Name
Tead3 ENSMUSG00000002249.11 Tead3
Tead4 ENSMUSG00000030353.9 Tead4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead3mm10_v2_chr17_-_28350600_283506810.695.5e-07Click!


Activity profile for motif Tead3_Tead4.

activity profile for motif Tead3_Tead4


Sorted Z-values histogram for motif Tead3_Tead4

Sorted Z-values for motif Tead3_Tead4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead3_Tead4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_24595623 37.880 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr14_-_54577578 35.159 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr10_+_24595434 30.859 ENSMUST00000020171.5
 Ctgf
connective tissue growth factor
chr12_-_80112998 29.455 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr5_-_137314175 27.834 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr11_+_98412461 26.341 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr3_-_145649970 24.081 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr4_-_43558386 23.343 ENSMUST00000130353.1
 Tln1
talin 1
chr10_-_78591945 23.258 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr11_+_112782182 22.870 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr18_-_78206408 22.237 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr2_+_20519776 21.311 ENSMUST00000114604.2
ENSMUST00000066509.3
 Etl4

enhancer trap locus 4

chr3_-_57575760 21.009 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr15_+_6386598 16.180 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr9_+_69454066 15.442 ENSMUST00000134907.1
 Anxa2
annexin A2
chr17_+_78508063 14.866 ENSMUST00000024880.9
 Vit
vitrin
chr1_-_72874877 14.194 ENSMUST00000027377.8
 Igfbp5
insulin-like growth factor binding protein 5
chr6_+_17306335 14.162 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr13_-_113046357 14.037 ENSMUST00000022282.3
 Gpx8
glutathione peroxidase 8 (putative)
chr3_-_57575907 13.102 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
17.2 68.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
6.5 45.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
4.9 34.1 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
9.8 29.5 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
4.6 27.8 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
8.8 26.3 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
5.2 25.9 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
3.2 25.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
5.2 25.8 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
6.0 24.1 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
4.7 23.3 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.2 23.0 GO:0048706 embryonic skeletal system development(GO:0048706)
11.4 22.9 GO:0072190 ureter urothelium development(GO:0072190) ureter morphogenesis(GO:0072197)
7.4 22.2 GO:0071918 urea transmembrane transport(GO:0071918)
3.2 16.2 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.2 14.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
2.1 14.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 12.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 11.9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.5 11.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 79.8 GO:0030055 cell-substrate junction(GO:0030055)
0.7 74.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.2 64.1 GO:0005801 cis-Golgi network(GO:0005801)
0.1 56.7 GO:0005667 transcription factor complex(GO:0005667)
2.0 26.3 GO:0043219 lateral loop(GO:0043219)
8.6 25.8 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
1.9 24.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.1 23.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 22.0 GO:0016459 myosin complex(GO:0016459)
0.1 17.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
4.0 16.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
1.2 16.2 GO:0005614 interstitial matrix(GO:0005614)
0.3 15.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 14.6 GO:0017053 transcriptional repressor complex(GO:0017053)
3.5 14.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 13.4 GO:0005871 kinesin complex(GO:0005871)
1.0 11.3 GO:0016600 flotillin complex(GO:0016600)
0.0 11.1 GO:0005730 nucleolus(GO:0005730)
1.5 10.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 10.2 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 107.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
2.7 35.2 GO:0045294 alpha-catenin binding(GO:0045294)
2.1 29.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 29.1 GO:0003774 motor activity(GO:0003774)
2.1 27.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
8.8 26.3 GO:0001042 RNA polymerase I core binding(GO:0001042)
5.2 25.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
6.4 25.8 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.1 24.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 23.8 GO:0003779 actin binding(GO:0003779)
2.6 23.3 GO:0030274 LIM domain binding(GO:0030274)
2.1 22.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
3.7 22.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 18.4 GO:0005096 GTPase activator activity(GO:0005096)
1.2 16.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 16.1 GO:0005539 glycosaminoglycan binding(GO:0005539)
1.1 15.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.6 14.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.3 13.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
1.3 11.9 GO:0008420 CTD phosphatase activity(GO:0008420)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 94.9 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.5 38.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 28.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 24.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
3.0 24.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.8 24.0 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
1.1 16.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.3 16.2 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.3 12.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.4 12.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 12.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 11.9 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 11.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.8 11.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 9.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 8.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 6.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 6.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 5.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 110.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 35.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.5 29.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
1.7 27.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.9 25.2 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
1.7 23.3 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
1.1 22.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.3 18.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.9 14.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8 14.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
1.6 12.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.4 11.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 10.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 10.7 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 10.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 9.3 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.3 8.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.6 7.6 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 7.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)