Motif ID: Tfap2a

Z-value: 1.127


Transcription factors associated with Tfap2a:

Gene SymbolEntrez IDGene Name
Tfap2a ENSMUSG00000021359.9 Tfap2a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2amm10_v2_chr13_-_40730416_407304290.315.2e-02Click!


Activity profile for motif Tfap2a.

activity profile for motif Tfap2a


Sorted Z-values histogram for motif Tfap2a

Sorted Z-values for motif Tfap2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_86498836 4.798 ENSMUST00000120638.1
 Syn3
synapsin III
chr1_+_159737510 4.446 ENSMUST00000111669.3
 Tnr
tenascin R
chr10_+_100015817 4.398 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr17_+_69969073 4.367 ENSMUST00000133983.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_+_69969387 4.243 ENSMUST00000146730.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_+_69969217 4.053 ENSMUST00000060072.5
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr5_-_146585239 4.050 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr9_+_21184103 3.775 ENSMUST00000115458.2
 Pde4a
phosphodiesterase 4A, cAMP specific
chr13_-_110280103 3.391 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr4_-_64046925 3.330 ENSMUST00000107377.3
 Tnc
tenascin C
chr12_+_40446050 3.205 ENSMUST00000037488.6
 Dock4
dedicator of cytokinesis 4
chr9_+_26733728 2.984 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr10_+_86021961 2.864 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr8_+_70493156 2.766 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr9_+_109931774 2.554 ENSMUST00000169851.2
 Map4
microtubule-associated protein 4
chr18_-_38601268 2.536 ENSMUST00000025295.6
 Spry4
sprouty homolog 4 (Drosophila)
chr10_+_81575306 2.526 ENSMUST00000146916.1
 Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr5_+_117841839 2.487 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr4_-_136956784 2.473 ENSMUST00000030420.8
 Epha8
Eph receptor A8
chr1_-_38836090 2.441 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 243 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 12.7 GO:0070842 aggresome assembly(GO:0070842)
0.3 5.7 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.2 5.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 5.4 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
1.3 5.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.1 4.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.1 4.4 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
1.3 4.0 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.1 4.0 GO:0017157 regulation of exocytosis(GO:0017157)
0.6 3.9 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.3 3.9 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 3.5 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.5 3.3 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 3.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.8 3.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.3 3.2 GO:0046959 habituation(GO:0046959)
0.4 2.9 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.5 2.8 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 2.8 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.5 2.7 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.8 GO:0014069 postsynaptic density(GO:0014069)
0.1 6.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 5.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 5.5 GO:0030175 filopodium(GO:0030175)
0.0 5.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
1.5 4.4 GO:0072534 perineuronal net(GO:0072534)
0.1 4.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 4.3 GO:0030426 growth cone(GO:0030426)
1.0 3.9 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 3.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.4 GO:0055037 recycling endosome(GO:0055037)
0.2 3.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.3 GO:0032420 stereocilium(GO:0032420)
0.0 3.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.6 2.9 GO:1990037 Lewy body core(GO:1990037)
0.1 2.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.9 2.8 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 2.8 GO:0016459 myosin complex(GO:0016459)
0.1 2.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 6.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.9 5.7 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 5.7 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 5.4 GO:0008017 microtubule binding(GO:0008017)
0.1 4.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.7 4.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.4 4.4 GO:0046625 sphingolipid binding(GO:0046625)
0.7 4.3 GO:0045545 syndecan binding(GO:0045545)
0.3 4.1 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.7 4.0 GO:0097001 ceramide binding(GO:0097001)
0.0 4.0 GO:0043130 ubiquitin binding(GO:0043130)
0.1 3.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.4 GO:0031489 myosin V binding(GO:0031489)
0.4 3.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)
0.4 2.8 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 2.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 2.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.8 2.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 4.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 4.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 4.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.0 ST_ADRENERGIC Adrenergic Pathway
0.1 3.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.6 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 2.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.2 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.7 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.4 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 5.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 5.7 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 5.3 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 4.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 4.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 3.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.5 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 3.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 3.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 2.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 2.4 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 2.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 2.4 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 2.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.8 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.8 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade