Motif ID: Tfap2b

Z-value: 0.785


Transcription factors associated with Tfap2b:

Gene SymbolEntrez IDGene Name
Tfap2b ENSMUSG00000025927.7 Tfap2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2bmm10_v2_chr1_+_19212054_19212106-0.603.6e-05Click!


Activity profile for motif Tfap2b.

activity profile for motif Tfap2b


Sorted Z-values histogram for motif Tfap2b

Sorted Z-values for motif Tfap2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_158610731 4.991 ENSMUST00000045738.4
 Slc32a1
solute carrier family 32 (GABA vesicular transporter), member 1
chr19_+_5740885 4.820 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr2_-_36105271 4.308 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr12_+_70825492 4.284 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr1_-_56978534 3.713 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr12_+_84009481 3.518 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr17_+_83215271 3.391 ENSMUST00000170794.1
 Pkdcc
protein kinase domain containing, cytoplasmic
chr4_+_48045144 2.903 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr5_-_37824580 2.599 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr2_+_59612034 2.536 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr1_-_56972437 2.459 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr17_+_86963279 2.446 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr2_+_91945703 2.414 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr7_-_27333602 2.231 ENSMUST00000118583.1
ENSMUST00000118961.1
ENSMUST00000121175.1
 Ltbp4


latent transforming growth factor beta binding protein 4


chr3_-_137981523 2.227 ENSMUST00000136613.1
ENSMUST00000029806.6
 Dapp1

dual adaptor for phosphotyrosine and 3-phosphoinositides 1

chr13_+_49187485 2.112 ENSMUST00000049022.8
ENSMUST00000120733.1
 Ninj1

ninjurin 1

chr1_-_14310198 2.027 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr7_+_78578830 1.838 ENSMUST00000064591.4
 Gm9885
predicted gene 9885
chr5_-_137314175 1.729 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr8_+_84723003 1.700 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 5.7 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.6 5.0 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
1.6 4.8 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.7 4.3 GO:0003383 apical constriction(GO:0003383)
0.1 4.0 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.6 3.9 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.6 3.4 GO:0090005 negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 3.3 GO:0097062 dendritic spine maintenance(GO:0097062)
1.0 2.9 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.9 2.6 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.2 2.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.4 2.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 2.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.3 2.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 2.0 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.2 1.9 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 1.8 GO:0060033 anatomical structure regression(GO:0060033)
0.0 1.8 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
0.3 1.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 6.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.9 4.6 GO:0044316 cone cell pedicle(GO:0044316)
0.0 4.6 GO:0043296 apical junction complex(GO:0043296)
0.0 3.0 GO:0005884 actin filament(GO:0005884)
0.0 2.3 GO:0031901 early endosome membrane(GO:0031901)
0.1 2.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 2.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.4 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 1.0 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.2 1.0 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 1.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 0.9 GO:0008091 spectrin(GO:0008091)
0.1 0.9 GO:0032433 filopodium tip(GO:0032433)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.7 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 5.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.7 5.0 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.3 3.6 GO:0005522 profilin binding(GO:0005522)
0.2 3.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 2.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 2.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 2.3 GO:0002039 p53 binding(GO:0002039)
0.1 2.1 GO:0050699 WW domain binding(GO:0050699)
0.0 2.1 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 2.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.9 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.5 1.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 1.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.5 GO:0005080 protein kinase C binding(GO:0005080)
0.3 1.4 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.3 1.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 6.1 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 4.7 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.1 2.1 PID_EPO_PATHWAY EPO signaling pathway
0.0 2.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.6 NABA_COLLAGENS Genes encoding collagen proteins
0.2 1.2 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.2 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.4 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 4.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 4.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.8 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 2.0 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.6 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.0 1.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.2 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.1 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.9 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.1 0.7 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression