Motif ID: Tfap2c
Z-value: 0.789
Transcription factors associated with Tfap2c:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tfap2c | ENSMUSG00000028640.5 | Tfap2c |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfap2c | mm10_v2_chr2_+_172550761_172550782 | -0.51 | 6.1e-04 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 110 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.9 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.6 | 4.1 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.2 | 3.5 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.6 | 2.8 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.0 | 2.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.4 | 2.3 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.3 | 2.1 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.7 | 2.0 | GO:0021837 | motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465) |
| 0.3 | 1.9 | GO:1902856 | negative regulation of nonmotile primary cilium assembly(GO:1902856) |
| 0.0 | 1.9 | GO:0003382 | epithelial cell morphogenesis(GO:0003382) |
| 0.3 | 1.8 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.2 | 1.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.4 | 1.7 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.4 | 1.7 | GO:0050904 | diapedesis(GO:0050904) |
| 0.1 | 1.7 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.0 | 1.7 | GO:0030041 | actin filament polymerization(GO:0030041) |
| 0.2 | 1.6 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.2 | 1.6 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.1 | 1.6 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.0 | 1.6 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 51 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.5 | GO:0005584 | collagen type I trimer(GO:0005584) |
| 0.2 | 4.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 3.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 3.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 2.8 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 2.6 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.8 | 2.3 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.1 | 2.1 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.3 | 1.9 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.0 | 1.8 | GO:0005884 | actin filament(GO:0005884) |
| 0.6 | 1.7 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.3 | 1.7 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 1.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 1.7 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 1.6 | GO:0042641 | actomyosin(GO:0042641) |
| 0.2 | 1.5 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 1.5 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 1.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 1.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.3 | 1.3 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 84 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 4.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 4.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 1.0 | 4.1 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.0 | 3.1 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 2.8 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 2.6 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.3 | 2.3 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.7 | 2.1 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.2 | 2.0 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.4 | 1.8 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.4 | 1.7 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.1 | 1.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 1.6 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.1 | 1.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 1.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.4 | 1.5 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.4 | 1.5 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.1 | 1.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 1.5 | GO:0030506 | ankyrin binding(GO:0030506) |
Gene overrepresentation in C2:CP category:
Showing 1 to 19 of 19 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 4.5 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 3.3 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 2.8 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.5 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.1 | 2.0 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.9 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 1.4 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.3 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 1.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.0 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.9 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.9 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.7 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.6 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.6 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.5 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.2 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 32 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.4 | 4.6 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 3.8 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 3.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.9 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 2.7 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 2.4 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 2.4 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 2.0 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 1.8 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.8 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.8 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.7 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 1.6 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 1.4 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 1.4 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 1.2 | REACTOME_DAG_AND_IP3_SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.1 | 1.1 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 1.1 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 1.1 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
