Motif ID: Tfap2d

Z-value: 0.763


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_191030430.251.2e-01Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_32222233 4.394 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr12_+_84009481 3.607 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr18_+_64340225 3.051 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr8_-_105637350 2.856 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr2_+_25180737 2.292 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr4_-_154636831 2.290 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr4_+_152008803 2.237 ENSMUST00000097773.3
 Klhl21
kelch-like 21
chr7_+_130936172 2.199 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr12_+_83987854 2.188 ENSMUST00000021649.7
 Acot2
acyl-CoA thioesterase 2
chr11_-_31370066 2.185 ENSMUST00000020546.2
 Stc2
stanniocalcin 2
chr9_-_79718631 1.904 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr2_+_26586607 1.883 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr19_+_38481057 1.872 ENSMUST00000182481.1
 Plce1
phospholipase C, epsilon 1
chr7_-_4789541 1.832 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr2_+_91257323 1.726 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr8_-_105637403 1.712 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr9_-_79718518 1.710 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr9_-_79718720 1.661 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr2_-_173276144 1.557 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr6_-_134632388 1.522 ENSMUST00000047443.3
 Mansc1
MANSC domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.1 3.6 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.5 3.2 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.3 3.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.5 2.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 2.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 2.3 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 2.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 2.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 2.2 GO:0006817 phosphate ion transport(GO:0006817)
0.1 2.2 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 1.9 GO:0032835 glomerulus development(GO:0032835)
0.3 1.7 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.2 1.7 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 1.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.5 1.6 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.0 1.6 GO:0006414 translational elongation(GO:0006414)
0.2 1.5 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.1 1.5 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 1.5 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 GO:0031012 extracellular matrix(GO:0031012)
1.8 5.3 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 4.0 GO:0000139 Golgi membrane(GO:0000139)
0.1 2.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.3 GO:0016235 aggresome(GO:0016235)
0.3 2.2 GO:0005827 polar microtubule(GO:0005827)
0.0 1.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.5 GO:0005814 centriole(GO:0005814)
0.1 1.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:0005884 actin filament(GO:0005884)
0.4 1.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 1.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.1 GO:0042555 MCM complex(GO:0042555)
0.0 1.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.0 GO:0035869 ciliary transition zone(GO:0035869)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.9 GO:0046930 pore complex(GO:0046930)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 4.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.0 GO:0020037 heme binding(GO:0020037)
0.1 2.7 GO:0050699 WW domain binding(GO:0050699)
0.1 2.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.2 GO:0005112 Notch binding(GO:0005112)
0.0 2.0 GO:0005109 frizzled binding(GO:0005109)
0.1 1.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.8 GO:0046332 SMAD binding(GO:0046332)
0.3 1.7 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 1.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.5 GO:0043495 protein anchor(GO:0043495)
0.1 1.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 1.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 1.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.3 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 3.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 1.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.7 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.2 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.2 1.1 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 1.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.1 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.1 PID_ATR_PATHWAY ATR signaling pathway
0.1 1.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.8 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 2.0 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.9 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 1.2 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 1.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.1 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.9 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.9 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 0.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.7 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 0.6 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.6 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery