Motif ID: Tfap2e

Z-value: 0.802


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.333.3e-02Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

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Top targets:


Showing 1 to 20 of 72 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_91945703 13.710 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr11_-_102897123 9.999 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr11_-_102897146 6.253 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr6_+_108213086 5.725 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr13_-_101768154 3.103 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr15_-_102524615 3.066 ENSMUST00000023814.7
 Npff
neuropeptide FF-amide peptide precursor
chr1_+_159737510 2.862 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_-_34187670 2.338 ENSMUST00000042701.6
ENSMUST00000119171.1
 Mxd4

Max dimerization protein 4

chr13_+_54949388 2.059 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr6_-_97617536 2.038 ENSMUST00000113355.2
 Frmd4b
FERM domain containing 4B
chr8_+_41239718 1.928 ENSMUST00000045218.7
 Pcm1
pericentriolar material 1
chr4_-_149774238 1.907 ENSMUST00000105686.2
 Slc25a33
solute carrier family 25, member 33
chr2_-_38287174 1.865 ENSMUST00000130472.1
 Dennd1a
DENN/MADD domain containing 1A
chr15_-_58214882 1.756 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr16_+_93832121 1.716 ENSMUST00000044068.6
 Morc3
microrchidia 3
chr9_-_97111117 1.689 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr3_-_113630068 1.604 ENSMUST00000092154.3
ENSMUST00000106536.1
ENSMUST00000106535.1
 Rnpc3


RNA-binding region (RNP1, RRM) containing 3


chr8_+_107293500 1.589 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chr2_+_102658640 1.554 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr8_+_107293463 1.550 ENSMUST00000169453.1
 Nfat5
nuclear factor of activated T cells 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 16.3 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.6 6.2 GO:0010459 negative regulation of heart rate(GO:0010459)
1.0 5.7 GO:0042045 epithelial fluid transport(GO:0042045)
0.9 3.6 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 3.1 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.7 2.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.4 2.9 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.8 2.5 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.3 2.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 2.0 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 2.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.3 1.9 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.3 1.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.6 1.8 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.7 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.2 1.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 1.5 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.7 1.4 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.1 1.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.4 1.2 GO:0071579 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) regulation of zinc ion transport(GO:0071579)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 16.3 GO:0097450 astrocyte end-foot(GO:0097450)
1.9 5.7 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 4.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
1.0 2.9 GO:0072534 perineuronal net(GO:0072534)
0.0 2.6 GO:0043204 perikaryon(GO:0043204)
0.1 2.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 2.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.9 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.9 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 1.6 GO:0030673 axolemma(GO:0030673)
0.3 1.5 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.4 GO:0034706 sodium channel complex(GO:0034706)
0.2 1.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 1.2 GO:0005776 autophagosome(GO:0005776)
0.1 1.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.9 5.7 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 3.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 3.6 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.8 3.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 3.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 2.9 GO:0046625 sphingolipid binding(GO:0046625)
0.1 2.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.5 2.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 2.1 GO:0005042 netrin receptor activity(GO:0005042)
0.3 1.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.6 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 1.5 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 1.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.4 1.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 1.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 1.1 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 1.0 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.8 GO:0097016 L27 domain binding(GO:0097016)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 3.1 PID_IL5_PATHWAY IL5-mediated signaling events
0.2 2.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.8 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.2 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 1.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 3.6 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.3 3.1 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.9 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 2.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 2.1 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.3 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC