Motif ID: Tfap4

Z-value: 1.251


Transcription factors associated with Tfap4:

Gene SymbolEntrez IDGene Name
Tfap4 ENSMUSG00000005718.7 Tfap4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap4mm10_v2_chr16_-_4559720_4559747-0.288.0e-02Click!


Activity profile for motif Tfap4.

activity profile for motif Tfap4


Sorted Z-values histogram for motif Tfap4

Sorted Z-values for motif Tfap4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_40346290 13.089 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr4_+_119814495 9.181 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr16_+_43510267 8.136 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr7_-_120202104 8.023 ENSMUST00000033198.5
 Crym
crystallin, mu
chr8_+_66386292 7.686 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr4_+_48045144 7.162 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr13_+_29014399 6.418 ENSMUST00000146336.1
ENSMUST00000130109.1
 A330102I10Rik

RIKEN cDNA A330102I10 gene

chr6_-_136171722 6.187 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr15_-_66812593 5.290 ENSMUST00000100572.3
 Sla
src-like adaptor
chr18_-_23041641 5.076 ENSMUST00000097651.3
 Nol4
nucleolar protein 4
chr7_-_97417730 4.985 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr10_+_69785507 4.936 ENSMUST00000182993.1
 Ank3
ankyrin 3, epithelial
chr15_+_80287234 4.850 ENSMUST00000160424.1
 Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr14_-_45219364 4.697 ENSMUST00000022377.4
ENSMUST00000143609.1
ENSMUST00000139526.1
 Txndc16


thioredoxin domain containing 16


chr8_+_12984246 4.568 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
 Mcf2l


mcf.2 transforming sequence-like


chr3_+_90537242 4.436 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr16_+_91269759 4.384 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr14_+_45219993 4.340 ENSMUST00000146150.1
 Gpr137c
G protein-coupled receptor 137C
chr9_+_45370185 4.253 ENSMUST00000085939.6
 Fxyd6
FXYD domain-containing ion transport regulator 6
chr7_+_144284385 4.118 ENSMUST00000097929.2
 Shank2
SH3/ankyrin domain gene 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.6 8.0 GO:0070327 thyroid hormone transport(GO:0070327)
0.4 7.7 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 7.7 GO:0051592 response to calcium ion(GO:0051592)
2.4 7.2 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 7.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
1.7 6.9 GO:0001920 negative regulation of receptor recycling(GO:0001920)
1.5 6.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 5.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 5.2 GO:0071625 vocalization behavior(GO:0071625)
0.2 5.0 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.4 4.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 4.8 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 4.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 4.6 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.2 4.2 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 4.2 GO:0008542 visual learning(GO:0008542)
0.1 4.1 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 4.0 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.8 3.9 GO:1902995 apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.1 GO:0005802 trans-Golgi network(GO:0005802)
0.1 10.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 7.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 7.7 GO:0005770 late endosome(GO:0005770)
0.0 6.5 GO:0043679 axon terminus(GO:0043679)
0.4 6.2 GO:0043083 synaptic cleft(GO:0043083)
0.2 4.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 4.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 4.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 4.5 GO:1990635 proximal dendrite(GO:1990635)
0.5 4.1 GO:0005883 neurofilament(GO:0005883)
0.2 3.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.8 GO:0043197 dendritic spine(GO:0043197)
0.1 3.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 3.7 GO:0005776 autophagosome(GO:0005776)
0.2 3.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 3.4 GO:0071564 npBAF complex(GO:0071564)
0.5 3.2 GO:0097512 cardiac myofibril(GO:0097512)
0.2 3.1 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 2.9 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 8.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.4 7.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 7.7 GO:0042287 MHC protein binding(GO:0042287)
0.8 6.9 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.2 6.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.8 6.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 5.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 5.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 5.1 GO:0005158 insulin receptor binding(GO:0005158)
1.2 4.8 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 4.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 4.5 GO:0070064 proline-rich region binding(GO:0070064)
1.0 4.1 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.1 4.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 4.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
1.3 3.9 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 3.8 GO:0017080 sodium channel regulator activity(GO:0017080)
1.2 3.7 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.6 3.7 GO:0005042 netrin receptor activity(GO:0005042)
0.2 3.6 GO:0005184 neuropeptide hormone activity(GO:0005184)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 8.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 7.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 6.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 5.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 4.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 2.4 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 2.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 2.0 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.2 1.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 1.7 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.5 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 5.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 3.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 2.4 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 2.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 2.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.1 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 2.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.2 1.9 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.9 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 1.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.7 REACTOME_FRS2_MEDIATED_CASCADE Genes involved in FRS2-mediated cascade