Motif ID: Tfdp1_Wt1_Egr2
Z-value: 2.159
Transcription factors associated with Tfdp1_Wt1_Egr2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Egr2 | ENSMUSG00000037868.9 | Egr2 |
| Tfdp1 | ENSMUSG00000038482.10 | Tfdp1 |
| Wt1 | ENSMUSG00000016458.7 | Wt1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfdp1 | mm10_v2_chr8_+_13339656_13339674 | 0.74 | 4.1e-08 | Click! |
| Egr2 | mm10_v2_chr10_+_67537861_67537930 | -0.18 | 2.6e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,242 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 29.6 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
| 0.3 | 28.8 | GO:0051028 | mRNA transport(GO:0051028) |
| 4.6 | 27.8 | GO:0072049 | comma-shaped body morphogenesis(GO:0072049) |
| 2.3 | 25.6 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 1.7 | 24.9 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 1.3 | 22.6 | GO:0021889 | olfactory bulb interneuron differentiation(GO:0021889) |
| 0.7 | 22.2 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 2.2 | 21.9 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 5.4 | 21.5 | GO:0003360 | brainstem development(GO:0003360) |
| 2.7 | 21.4 | GO:0003149 | membranous septum morphogenesis(GO:0003149) |
| 0.9 | 20.9 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 2.6 | 20.7 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 6.7 | 20.0 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 4.8 | 19.2 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.5 | 19.2 | GO:1902808 | positive regulation of cell cycle G1/S phase transition(GO:1902808) |
| 2.1 | 18.9 | GO:0003263 | cardioblast proliferation(GO:0003263) regulation of cardioblast proliferation(GO:0003264) |
| 3.7 | 18.7 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.6 | 18.7 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.5 | 16.5 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.4 | 15.5 | GO:0034605 | cellular response to heat(GO:0034605) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 405 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 185.1 | GO:0005634 | nucleus(GO:0005634) |
| 0.6 | 52.5 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 36.6 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 1.3 | 31.7 | GO:0001741 | XY body(GO:0001741) |
| 0.4 | 27.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.6 | 23.9 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 23.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 21.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 6.9 | 20.8 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 3.4 | 20.5 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.6 | 20.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.2 | 20.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 1.3 | 18.9 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.5 | 18.9 | GO:0000791 | euchromatin(GO:0000791) |
| 0.2 | 17.7 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.2 | 17.4 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.1 | 17.2 | GO:0000228 | nuclear chromosome(GO:0000228) |
| 0.3 | 17.0 | GO:0031519 | PcG protein complex(GO:0031519) |
| 1.4 | 16.3 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.3 | 16.2 | GO:0005844 | polysome(GO:0005844) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 656 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 40.9 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.9 | 36.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.4 | 32.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 31.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.4 | 30.7 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 2.2 | 29.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 27.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.6 | 26.2 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.4 | 24.7 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 4.9 | 24.3 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
| 2.6 | 23.8 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 2.8 | 22.5 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 1.3 | 22.1 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.9 | 21.8 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.3 | 21.8 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 3.6 | 21.6 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 0.7 | 21.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.4 | 21.6 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.6 | 21.3 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 1.7 | 21.0 | GO:0031996 | thioesterase binding(GO:0031996) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 117 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 65.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 53.8 | PID_E2F_PATHWAY | E2F transcription factor network |
| 1.7 | 49.7 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.9 | 41.8 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.9 | 37.4 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.6 | 31.6 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.7 | 28.9 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.7 | 28.5 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.7 | 26.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.5 | 26.1 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.5 | 25.1 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.6 | 24.5 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 1.7 | 23.9 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.7 | 22.9 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.4 | 22.3 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.7 | 21.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.4 | 21.0 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.5 | 18.9 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.5 | 18.8 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.6 | 18.6 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 176 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 66.7 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 1.2 | 42.0 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 1.5 | 32.1 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 30.6 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 28.6 | REACTOME_DIABETES_PATHWAYS | Genes involved in Diabetes pathways |
| 1.4 | 27.7 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 1.0 | 26.3 | REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.5 | 26.2 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.8 | 23.6 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 1.2 | 22.3 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.9 | 21.3 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.8 | 20.0 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 1.1 | 19.4 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 1.4 | 19.0 | REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.4 | 18.9 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.4 | 18.6 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.4 | 18.0 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 16.7 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.6 | 16.5 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.3 | 16.5 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
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