Motif ID: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.252

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2:

Gene SymbolEntrez IDGene Name
Bhlhe41 ENSMUSG00000030256.5 Bhlhe41
Srebf1 ENSMUSG00000020538.9 Srebf1
Srebf2 ENSMUSG00000022463.7 Srebf2
Tfeb ENSMUSG00000023990.12 Tfeb
Usf1 ENSMUSG00000026641.7 Usf1
Usf2 ENSMUSG00000058239.7 Usf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Usf2mm10_v2_chr7_-_30956742_30956803-0.516.5e-04Click!
Srebf2mm10_v2_chr15_+_82147238_821472750.324.1e-02Click!
Usf1mm10_v2_chr1_+_171411343_171411384-0.261.0e-01Click!
Srebf1mm10_v2_chr11_-_60210410_602104650.182.7e-01Click!
Tfebmm10_v2_chr17_+_47737030_47737107-0.124.7e-01Click!


Activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2.

activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2


Sorted Z-values histogram for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Sorted Z-values for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_89773221 14.736 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr17_-_66077022 12.487 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr4_-_148038769 12.018 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr2_+_4300462 10.579 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr4_+_148039035 10.472 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr16_-_45158183 10.327 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr16_-_45158566 9.596 ENSMUST00000181177.1
 Slc35a5
solute carrier family 35, member A5
chr15_+_66577536 9.340 ENSMUST00000048188.8
 Phf20l1
PHD finger protein 20-like 1
chr16_-_45158624 9.072 ENSMUST00000180636.1
 Slc35a5
solute carrier family 35, member A5
chr4_+_148039097 8.822 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_127077374 8.757 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr5_-_136170634 8.625 ENSMUST00000041048.1
 Orai2
ORAI calcium release-activated calcium modulator 2
chr15_-_3995708 8.382 ENSMUST00000046633.8
 AW549877
expressed sequence AW549877
chr16_-_45158650 8.224 ENSMUST00000023344.3
 Slc35a5
solute carrier family 35, member A5
chr10_+_111164794 7.823 ENSMUST00000105275.1
ENSMUST00000095310.1
 Osbpl8

oxysterol binding protein-like 8

chr16_-_45158453 7.820 ENSMUST00000181750.1
 Slc35a5
solute carrier family 35, member A5
chr2_-_164833438 7.701 ENSMUST00000042775.4
 Neurl2
neuralized-like 2 (Drosophila)
chr15_-_77956658 7.255 ENSMUST00000117725.1
ENSMUST00000016696.6
 Foxred2

FAD-dependent oxidoreductase domain containing 2

chr16_-_93794882 7.113 ENSMUST00000180967.1
 2310043M15Rik
RIKEN cDNA 2310043M15 gene
chr11_+_53350783 7.064 ENSMUST00000060945.5
 Aff4
AF4/FMR2 family, member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 401 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 42.2 GO:0008643 carbohydrate transport(GO:0008643)
0.8 25.9 GO:0097352 autophagosome maturation(GO:0097352)
0.5 22.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.6 19.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.7 19.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
4.8 19.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.2 17.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 17.3 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
4.0 11.9 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.3 11.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 10.7 GO:0036465 synaptic vesicle recycling(GO:0036465)
2.1 10.5 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.2 10.5 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
3.4 10.3 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
1.4 9.9 GO:0045346 regulation of MHC class II biosynthetic process(GO:0045346)
0.3 9.4 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
2.3 9.2 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 9.2 GO:0007596 blood coagulation(GO:0007596)
0.8 8.6 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
2.1 8.4 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 37.2 GO:0000139 Golgi membrane(GO:0000139)
0.1 26.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 23.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.9 16.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
2.1 15.0 GO:0033263 CORVET complex(GO:0033263)
0.4 13.6 GO:0035861 site of double-strand break(GO:0035861)
2.8 11.4 GO:0031084 BLOC-2 complex(GO:0031084)
1.1 11.1 GO:0071141 SMAD protein complex(GO:0071141)
0.2 10.4 GO:0005905 clathrin-coated pit(GO:0005905)
2.5 10.1 GO:0019034 viral replication complex(GO:0019034)
0.8 10.1 GO:1990635 proximal dendrite(GO:1990635)
1.1 9.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 9.6 GO:0030427 site of polarized growth(GO:0030427)
0.6 9.2 GO:0043196 varicosity(GO:0043196)
0.3 9.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 9.0 GO:0055037 recycling endosome(GO:0055037)
0.8 7.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
2.6 7.7 GO:0005927 muscle tendon junction(GO:0005927)
0.0 7.7 GO:0045202 synapse(GO:0045202)
0.4 7.1 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 258 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 45.6 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 41.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.9 21.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
6.4 19.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
1.2 19.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.8 17.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 17.0 GO:0008565 protein transporter activity(GO:0008565)
0.1 12.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
1.7 12.0 GO:0033592 RNA strand annealing activity(GO:0033592)
1.1 11.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 11.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
3.4 10.3 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.2 10.0 GO:0005262 calcium channel activity(GO:0005262)
0.4 9.7 GO:0070064 proline-rich region binding(GO:0070064)
0.1 9.7 GO:0019905 syntaxin binding(GO:0019905)
0.1 9.1 GO:0008017 microtubule binding(GO:0008017)
0.1 8.8 GO:0030674 protein binding, bridging(GO:0030674)
1.2 8.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
2.9 8.6 GO:0035500 MH2 domain binding(GO:0035500)
0.1 8.5 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.7 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.2 12.1 PID_LKB1_PATHWAY LKB1 signaling events
0.1 9.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 6.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 5.6 PID_IL2_1PATHWAY IL2-mediated signaling events
0.2 5.5 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 4.4 PID_P73PATHWAY p73 transcription factor network
0.0 4.1 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 3.9 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 3.7 PID_FOXO_PATHWAY FoxO family signaling
0.2 3.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 3.2 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 2.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 2.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 2.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 2.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.9 PID_RB_1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 21.0 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.3 18.5 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 10.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.6 10.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.7 10.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 9.9 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ Genes involved in Formation of RNA Pol II elongation complex
0.1 9.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 8.4 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 6.6 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.5 6.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4 5.8 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.6 5.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.3 5.6 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 5.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 4.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 4.6 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 4.6 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.4 4.5 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.1 4.3 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 4.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors