Motif ID: Tgif1_Meis3

Z-value: 3.446

Transcription factors associated with Tgif1_Meis3:

Gene SymbolEntrez IDGene Name
Meis3 ENSMUSG00000041420.12 Meis3
Tgif1 ENSMUSG00000047407.11 Tgif1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif1mm10_v2_chr17_-_70851710_70851738-0.897.0e-15Click!
Meis3mm10_v2_chr7_+_16175085_161751390.551.9e-04Click!


Activity profile for motif Tgif1_Meis3.

activity profile for motif Tgif1_Meis3


Sorted Z-values histogram for motif Tgif1_Meis3

Sorted Z-values for motif Tgif1_Meis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif1_Meis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_49246131 35.942 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr15_+_18818895 21.715 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr15_-_66831625 19.734 ENSMUST00000164163.1
 Sla
src-like adaptor
chr1_-_132542934 17.149 ENSMUST00000086521.4
 Cntn2
contactin 2
chr15_-_58076456 17.083 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1

chr7_+_49246812 16.878 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr15_-_66801577 15.332 ENSMUST00000168589.1
 Sla
src-like adaptor
chr4_-_82705735 14.076 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr11_+_105589970 13.176 ENSMUST00000168598.1
ENSMUST00000100330.3
 Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr18_+_34247685 12.598 ENSMUST00000066133.6
 Apc
adenomatosis polyposis coli
chr7_+_112225856 12.512 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr13_-_97747399 12.453 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_-_116968827 12.139 ENSMUST00000119557.1
 Palmd
palmdelphin
chr3_-_116968969 11.937 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr3_+_26331150 11.485 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr16_-_91011308 11.100 ENSMUST00000121759.1
 Synj1
synaptojanin 1
chr6_-_53068562 10.726 ENSMUST00000074541.5
 Jazf1
JAZF zinc finger 1
chr10_+_69787431 10.699 ENSMUST00000183240.1
 Ank3
ankyrin 3, epithelial
chr19_+_28835074 10.610 ENSMUST00000025875.4
 Slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr8_-_84800024 10.538 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 621 entries
Log-likelihood per target Total log-likelihoodTermDescription
13.2 52.8 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
9.3 37.3 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
1.1 34.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.3 26.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 24.8 GO:0006376 mRNA splice site selection(GO:0006376)
1.7 21.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 20.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
2.5 19.9 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
6.0 18.0 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.7 17.2 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
5.7 17.1 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167)
0.9 16.9 GO:0097090 presynaptic membrane organization(GO:0097090)
1.0 16.3 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
1.7 15.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.4 14.5 GO:0046513 ceramide biosynthetic process(GO:0046513)
2.1 14.4 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
2.9 14.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.9 14.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
1.3 14.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
3.5 14.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 227 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 221.7 GO:0016021 integral component of membrane(GO:0016021)
3.6 57.7 GO:0005614 interstitial matrix(GO:0005614)
0.2 46.3 GO:0030427 site of polarized growth(GO:0030427)
1.3 45.6 GO:0090544 BAF-type complex(GO:0090544)
1.5 44.5 GO:0033268 node of Ranvier(GO:0033268)
0.2 40.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 40.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 31.3 GO:0001650 fibrillar center(GO:0001650)
1.3 30.9 GO:0030132 clathrin coat of coated pit(GO:0030132)
1.7 23.1 GO:0016342 catenin complex(GO:0016342)
0.1 18.0 GO:0005802 trans-Golgi network(GO:0005802)
0.6 17.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.8 16.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 16.0 GO:0043197 dendritic spine(GO:0043197)
0.6 15.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 14.8 GO:0005801 cis-Golgi network(GO:0005801)
2.3 13.9 GO:0097443 sorting endosome(GO:0097443)
1.5 13.1 GO:0042587 glycogen granule(GO:0042587)
0.3 12.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 12.9 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 379 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 54.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 52.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 33.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.0 32.5 GO:0030552 cAMP binding(GO:0030552)
0.8 29.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 29.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
5.4 27.2 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.3 26.8 GO:0008201 heparin binding(GO:0008201)
0.5 26.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 24.4 GO:0030507 spectrin binding(GO:0030507)
1.0 23.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.9 23.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 20.6 GO:0005509 calcium ion binding(GO:0005509)
0.9 19.1 GO:0071949 FAD binding(GO:0071949)
0.2 19.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.7 18.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
1.3 15.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.5 15.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.6 14.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.2 14.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 43.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 37.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6 33.6 SIG_CHEMOTAXIS Genes related to chemotaxis
0.6 32.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.5 23.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 21.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.6 16.4 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.5 16.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.6 13.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 12.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 12.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.4 12.4 PID_ARF_3PATHWAY Arf1 pathway
0.2 11.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.4 11.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 8.5 PID_BCR_5PATHWAY BCR signaling pathway
0.2 8.1 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.8 7.6 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.3 7.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.3 7.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 7.1 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 38.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
1.1 38.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.9 30.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.7 26.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.7 24.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 20.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.5 20.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.7 18.0 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 16.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 16.7 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
1.0 15.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.6 15.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.4 14.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.3 13.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 12.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.7 12.6 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.3 12.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.6 12.0 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.3 11.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 11.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling