Motif ID: Tgif2_Tgif2lx1_Tgif2lx2

Z-value: 0.770

Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:

Gene SymbolEntrez IDGene Name
Tgif2 ENSMUSG00000062175.7 Tgif2
Tgif2lx1 ENSMUSG00000061283.4 Tgif2lx1
Tgif2lx2 ENSMUSG00000063242.6 Tgif2lx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif2mm10_v2_chr2_+_156840077_156840141-0.314.6e-02Click!


Activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2.

activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2


Sorted Z-values histogram for motif Tgif2_Tgif2lx1_Tgif2lx2

Sorted Z-values for motif Tgif2_Tgif2lx1_Tgif2lx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 187 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_19103022 8.614 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr2_+_82053222 3.292 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr17_+_86753900 3.146 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr15_+_85510812 2.957 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr5_-_45857473 2.869 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
 Lcorl


ligand dependent nuclear receptor corepressor-like


chr11_+_115154139 2.679 ENSMUST00000021076.5
 Rab37
RAB37, member of RAS oncogene family
chr5_-_100159261 2.624 ENSMUST00000139520.1
 Tmem150c
transmembrane protein 150C
chr13_-_76385028 2.595 ENSMUST00000099365.1
 Gm10760
predicted gene 10760
chr7_-_44670820 2.052 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr7_+_51621830 1.888 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_-_52727457 1.821 ENSMUST00000156876.1
ENSMUST00000087701.3
 Mfsd6

major facilitator superfamily domain containing 6

chr9_+_78175898 1.729 ENSMUST00000180974.1
 C920006O11Rik
RIKEN cDNA C920006O11 gene
chr13_+_54949388 1.709 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr6_-_106800051 1.658 ENSMUST00000013882.7
ENSMUST00000049675.4
ENSMUST00000113239.3
 Crbn


cereblon


chr6_-_88875035 1.564 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr7_-_61982348 1.550 ENSMUST00000181804.1
ENSMUST00000181187.1
 A330076H08Rik

RIKEN cDNA A330076H08 gene

chr17_+_87025550 1.517 ENSMUST00000024959.3
ENSMUST00000160269.1
 Cript

cysteine-rich PDZ-binding protein

chr7_-_61982290 1.379 ENSMUST00000180481.1
 A330076H08Rik
RIKEN cDNA A330076H08 gene
chr17_-_6477102 1.342 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr17_-_36989504 1.302 ENSMUST00000169189.1
 H2-M5
histocompatibility 2, M region locus 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 GO:0030901 midbrain development(GO:0030901)
0.6 3.1 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.3 3.0 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 2.8 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 2.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 2.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 2.1 GO:0071625 vocalization behavior(GO:0071625)
0.1 2.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 1.9 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 1.7 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 1.7 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.3 1.5 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.4 1.3 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 1.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.1 1.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.3 GO:0048246 macrophage chemotaxis(GO:0048246)
0.4 1.2 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.3 1.2 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.0 1.2 GO:0071480 cellular response to gamma radiation(GO:0071480)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.1 GO:0005667 transcription factor complex(GO:0005667)
0.2 3.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.7 GO:0030667 secretory granule membrane(GO:0030667)
0.3 2.1 GO:0097513 myosin II filament(GO:0097513)
0.1 2.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.7 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 1.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.3 GO:0005871 kinesin complex(GO:0005871)
0.1 1.0 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.2 0.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.9 GO:0031045 dense core granule(GO:0031045)
0.0 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.4 GO:0042587 glycogen granule(GO:0042587)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.4 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0050897 cobalt ion binding(GO:0050897)
0.3 3.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 2.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 2.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.3 1.7 GO:0005042 netrin receptor activity(GO:0005042)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.4 1.3 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.2 1.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 1.3 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 1.1 GO:0070728 leucine binding(GO:0070728)
0.1 1.0 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 0.8 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.2 0.8 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.0 0.8 GO:0050840 extracellular matrix binding(GO:0050840)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_BCR_5PATHWAY BCR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 3.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 2.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.1 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.0 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol