Motif ID: Thra

Z-value: 0.570


Transcription factors associated with Thra:

Gene SymbolEntrez IDGene Name
Thra ENSMUSG00000058756.7 Thra

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thramm10_v2_chr11_+_98741805_98741816-0.542.6e-04Click!


Activity profile for motif Thra.

activity profile for motif Thra


Sorted Z-values histogram for motif Thra

Sorted Z-values for motif Thra



Network of associatons between targets according to the STRING database.



First level regulatory network of Thra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_57142782 2.693 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr1_+_84839833 2.275 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr4_+_44300876 1.988 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr10_-_92162753 1.897 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr14_-_118052235 1.622 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr13_+_94875600 1.617 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr4_-_137766474 1.592 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr17_+_85620816 1.572 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr10_+_93641041 1.483 ENSMUST00000020204.4
 Ntn4
netrin 4
chr12_-_111672290 1.385 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr7_-_141214080 1.320 ENSMUST00000026573.5
ENSMUST00000170841.1
 1600016N20Rik

RIKEN cDNA 1600016N20 gene

chr11_+_40733936 1.281 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2
chr17_-_32388885 1.252 ENSMUST00000087703.5
ENSMUST00000170603.1
 Wiz

widely-interspaced zinc finger motifs

chr1_-_84839304 1.229 ENSMUST00000027421.6
 Trip12
thyroid hormone receptor interactor 12
chr12_+_112678803 1.228 ENSMUST00000174780.1
ENSMUST00000169593.1
ENSMUST00000173942.1
 Zbtb42


zinc finger and BTB domain containing 42


chr1_+_131910458 1.197 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr6_+_113531675 1.143 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr13_-_99900645 1.113 ENSMUST00000022150.6
 Cartpt
CART prepropeptide
chr5_-_74065736 1.100 ENSMUST00000145016.1
 Usp46
ubiquitin specific peptidase 46
chr10_-_88146867 1.093 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.7 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.0 2.6 GO:0006457 protein folding(GO:0006457)
0.0 2.0 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.3 1.8 GO:0007296 vitellogenesis(GO:0007296)
0.5 1.6 GO:0097402 neuroblast migration(GO:0097402)
0.3 1.6 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 1.6 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 1.6 GO:0046677 endochondral ossification(GO:0001958) replacement ossification(GO:0036075) response to antibiotic(GO:0046677)
0.3 1.5 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 1.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 1.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 1.4 GO:0051639 actin filament network formation(GO:0051639)
0.2 1.3 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.4 1.2 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.4 1.2 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.4 1.1 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.2 1.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.2 1.1 GO:0008343 adult feeding behavior(GO:0008343)
0.1 1.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.1 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0001891 phagocytic cup(GO:0001891)
0.0 2.4 GO:0000776 kinetochore(GO:0000776)
0.0 2.4 GO:0030496 midbody(GO:0030496)
0.2 1.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.6 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 1.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.1 GO:0000793 condensed chromosome(GO:0000793)
0.2 1.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 1.0 GO:0042587 glycogen granule(GO:0042587)
0.0 1.0 GO:0043194 axon initial segment(GO:0043194)
0.0 1.0 GO:0005604 basement membrane(GO:0005604)
0.0 0.9 GO:0016514 SWI/SNF complex(GO:0016514)
0.3 0.8 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.8 GO:0000922 spindle pole(GO:0000922)
0.0 0.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0051082 unfolded protein binding(GO:0051082)
0.4 2.7 GO:0001849 complement component C1q binding(GO:0001849)
0.0 2.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.4 1.6 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 1.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 1.5 GO:0043237 laminin-1 binding(GO:0043237)
0.0 1.5 GO:0032452 histone demethylase activity(GO:0032452)
0.3 1.4 GO:0004111 creatine kinase activity(GO:0004111)
0.0 1.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 1.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 1.0 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 1.0 GO:0043495 protein anchor(GO:0043495)
0.1 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.1 0.8 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.8 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.8 PID_ATM_PATHWAY ATM pathway
0.0 1.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 0.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.2 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 1.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.3 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.3 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME_PERK_REGULATED_GENE_EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis