Motif ID: Tlx1

Z-value: 0.637


Transcription factors associated with Tlx1:

Gene SymbolEntrez IDGene Name
Tlx1 ENSMUSG00000025215.9 Tlx1



Activity profile for motif Tlx1.

activity profile for motif Tlx1


Sorted Z-values histogram for motif Tlx1

Sorted Z-values for motif Tlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_97450136 3.427 ENSMUST00000107601.1
 Arhgap23
Rho GTPase activating protein 23
chr2_+_82053222 2.406 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr8_-_109251698 2.167 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr3_+_156562141 1.949 ENSMUST00000175773.1
 Negr1
neuronal growth regulator 1
chr6_+_54681687 1.888 ENSMUST00000046276.6
 2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr8_-_57962564 1.884 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr4_+_48045144 1.770 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_-_136956784 1.750 ENSMUST00000030420.8
 Epha8
Eph receptor A8
chr12_-_78983476 1.748 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr2_+_120629113 1.713 ENSMUST00000150912.1
ENSMUST00000180041.1
 Stard9

START domain containing 9

chr19_-_5924797 1.685 ENSMUST00000055458.4
 Cdc42ep2
CDC42 effector protein (Rho GTPase binding) 2
chr2_+_118663235 1.671 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr7_-_4844665 1.670 ENSMUST00000066041.5
ENSMUST00000172377.1
 Shisa7

shisa homolog 7 (Xenopus laevis)

chr1_-_75278345 1.668 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chr3_+_123267445 1.641 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chrX_-_73880831 1.617 ENSMUST00000102871.3
 L1cam
L1 cell adhesion molecule
chr11_-_116654245 1.613 ENSMUST00000021166.5
 Cygb
cytoglobin
chr8_+_84415348 1.526 ENSMUST00000121390.1
ENSMUST00000122053.1
 Cacna1a

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

chr9_+_21165714 1.490 ENSMUST00000039413.8
 Pde4a
phosphodiesterase 4A, cAMP specific
chr12_+_95692212 1.436 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 2.9 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.4 2.5 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 2.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.4 2.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.3 2.2 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.6 1.9 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.6 1.8 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 1.7 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 1.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.7 GO:0051225 spindle assembly(GO:0051225)
0.0 1.7 GO:0007613 memory(GO:0007613)
0.5 1.6 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.4 1.6 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.3 1.6 GO:0015671 oxygen transport(GO:0015671)
0.2 1.6 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 1.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 1.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 1.5 GO:0046950 cellular ketone body metabolic process(GO:0046950)
0.2 1.4 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.6 GO:0005871 kinesin complex(GO:0005871)
0.0 2.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 1.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 1.7 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.3 1.6 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 1.6 GO:0044294 dendritic growth cone(GO:0044294)
0.1 1.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.3 GO:0071565 nBAF complex(GO:0071565)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 1.2 GO:0043512 inhibin A complex(GO:0043512)
0.0 1.2 GO:0097546 ciliary base(GO:0097546)
0.0 1.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.1 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 1.1 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.0 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 2.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.4 1.6 GO:0004096 catalase activity(GO:0004096)
0.3 1.6 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.5 GO:0042056 chemoattractant activity(GO:0042056)
0.2 1.4 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 1.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.3 GO:0030507 spectrin binding(GO:0030507)
0.3 1.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.2 1.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.3 1.1 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 1.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.7 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.6 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.9 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.4 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 1.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.5 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 1.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.2 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.2 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.8 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways