Motif ID: Tlx2

Z-value: 0.715


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48662740 3.630 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_117342831 2.728 ENSMUST00000178884.1
 Rasgrp1
RAS guanyl releasing protein 1
chr14_+_46760526 2.714 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr3_+_134236483 2.703 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr2_-_117342949 2.685 ENSMUST00000102534.4
 Rasgrp1
RAS guanyl releasing protein 1
chr14_-_34374617 2.102 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr14_+_115042752 1.973 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr4_+_154960915 1.953 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr2_-_117342709 1.776 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr6_-_72390659 1.680 ENSMUST00000059983.9
 Vamp8
vesicle-associated membrane protein 8
chr3_+_159839729 1.557 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr5_+_146845071 1.510 ENSMUST00000031646.7
 Rasl11a
RAS-like, family 11, member A
chr8_-_105637403 1.486 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr3_+_69004711 1.471 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr6_+_56017489 1.456 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr9_+_7764041 1.441 ENSMUST00000052865.9
 Tmem123
transmembrane protein 123
chr1_+_134962553 1.441 ENSMUST00000027687.7
 Ube2t
ubiquitin-conjugating enzyme E2T (putative)
chr3_-_98339921 1.414 ENSMUST00000065793.5
 Phgdh
3-phosphoglycerate dehydrogenase
chr12_+_109540979 1.379 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
 Meg3


maternally expressed 3


chr7_-_98309471 1.371 ENSMUST00000033020.7
 Acer3
alkaline ceramidase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 7.2 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
1.2 4.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 3.0 GO:0007050 cell cycle arrest(GO:0007050)
0.3 2.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 2.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 2.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 2.2 GO:0032543 mitochondrial translation(GO:0032543)
0.4 2.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 2.1 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.5 2.0 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.6 1.9 GO:1903048 regulation of acetylcholine-gated cation channel activity(GO:1903048)
0.6 1.9 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.1 1.9 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.6 1.7 GO:0090187 zymogen granule exocytosis(GO:0070625) positive regulation of pancreatic juice secretion(GO:0090187)
0.0 1.7 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 1.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.7 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.5 1.6 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.0 1.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.4 1.5 GO:0043973 histone H3-K4 acetylation(GO:0043973)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.4 GO:0030426 growth cone(GO:0030426)
0.4 4.0 GO:0000796 condensin complex(GO:0000796)
0.1 2.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 2.8 GO:0000242 pericentriolar material(GO:0000242)
0.1 2.3 GO:0071011 precatalytic spliceosome(GO:0071011)
0.4 2.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 2.2 GO:0043209 myelin sheath(GO:0043209)
0.2 2.1 GO:0005642 annulate lamellae(GO:0005642)
0.0 2.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 1.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.8 GO:0043679 axon terminus(GO:0043679)
0.2 1.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 1.7 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 1.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.5 GO:0005681 spliceosomal complex(GO:0005681)
0.4 1.4 GO:0071942 XPC complex(GO:0071942)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 7.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 5.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 3.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 2.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.4 2.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 2.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 2.2 GO:0030165 PDZ domain binding(GO:0030165)
0.4 2.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 2.0 GO:0046983 protein dimerization activity(GO:0046983)
0.3 1.9 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.2 1.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.3 1.8 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 1.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 1.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 1.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 1.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.3 1.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.5 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 3.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.1 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 1.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.6 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.3 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 0.9 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.9 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.1 0.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 7.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 3.2 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.2 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.3 2.1 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.1 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 2.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 1.9 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 1.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.2 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds