Motif ID: Trp63

Z-value: 0.534


Transcription factors associated with Trp63:

Gene SymbolEntrez IDGene Name
Trp63 ENSMUSG00000022510.8 Trp63



Activity profile for motif Trp63.

activity profile for motif Trp63


Sorted Z-values histogram for motif Trp63

Sorted Z-values for motif Trp63



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp63

PNG image of the network

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Top targets:


Showing 1 to 20 of 43 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_29090969 3.874 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr5_-_5265224 2.694 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr12_-_108003414 2.578 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr7_-_116038734 2.251 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr5_-_5266038 2.129 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chr13_-_103334429 2.077 ENSMUST00000167058.1
ENSMUST00000164111.1
 Mast4

microtubule associated serine/threonine kinase family member 4

chr12_-_108003594 1.897 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr7_-_141443314 1.634 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr8_-_87959560 1.313 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr14_-_122451109 1.019 ENSMUST00000081580.2
 Gm5089
predicted gene 5089
chr10_-_61452658 1.013 ENSMUST00000167087.1
ENSMUST00000020288.7
 Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr19_+_53140430 1.009 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr11_-_101466222 0.938 ENSMUST00000040430.7
 Vat1
vesicle amine transport protein 1 homolog (T californica)
chr2_+_59612034 0.875 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr3_-_108402589 0.872 ENSMUST00000147565.1
 Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr10_-_80671976 0.797 ENSMUST00000003433.6
 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr11_-_106487833 0.788 ENSMUST00000106801.1
 Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr7_-_126160992 0.736 ENSMUST00000164741.1
 Xpo6
exportin 6
chr6_+_34709610 0.726 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr7_-_37772868 0.724 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.7 4.5 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.4 3.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.2 2.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3 1.3 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 1.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 1.0 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 0.9 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.2 0.9 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.9 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.9 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 0.8 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.6 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 0.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.4 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 0.3 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.0 0.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 4.8 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
1.3 3.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 1.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 1.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 4.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
1.3 3.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 1.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 1.0 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 1.0 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.6 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.4 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.3 REACTOME_UNFOLDED_PROTEIN_RESPONSE Genes involved in Unfolded Protein Response
0.0 0.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 0.6 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport