Motif ID: Twist1

Z-value: 0.948


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_339576710.192.3e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_60794468 4.831 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_+_4119525 4.379 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr7_+_4119556 4.367 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr6_-_95718800 4.191 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr1_-_119053339 3.802 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr2_-_172940299 3.759 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr11_-_59290746 3.730 ENSMUST00000010044.7
 Wnt3a
wingless-related MMTV integration site 3A
chr19_+_25610533 3.706 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chrX_+_100730178 3.621 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr9_-_54661870 3.534 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_+_45216671 3.416 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr9_-_114844090 3.399 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr18_+_60911757 2.677 ENSMUST00000040359.5
 Arsi
arylsulfatase i
chr16_+_78930940 2.625 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr10_-_127030813 2.553 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr7_-_127218390 2.400 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr9_-_44342332 2.396 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase
chr7_-_127218303 2.289 ENSMUST00000106313.1
 Sept1
septin 1
chr1_+_74791516 2.132 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr9_-_54661666 2.074 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:1902476 chloride transmembrane transport(GO:1902476)
1.4 5.8 GO:0060032 notochord regression(GO:0060032)
0.6 5.8 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 5.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.3 4.8 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
1.2 4.7 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
1.1 4.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.5 4.2 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
1.3 3.8 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.2 3.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043)
0.4 3.6 GO:0090527 actin filament reorganization(GO:0090527)
0.7 3.4 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 3.4 GO:0030903 notochord development(GO:0030903)
0.1 3.1 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.3 2.5 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.2 2.5 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 2.5 GO:0048255 mRNA stabilization(GO:0048255)
0.2 2.4 GO:0018065 protein-cofactor linkage(GO:0018065)
0.2 2.1 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.7 2.0 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 8.7 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 6.8 GO:0031012 extracellular matrix(GO:0031012)
0.4 5.8 GO:0097542 ciliary tip(GO:0097542)
0.0 5.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.2 4.8 GO:0043293 apoptosome(GO:0043293)
0.5 4.7 GO:0072687 meiotic spindle(GO:0072687)
0.7 4.2 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
1.2 3.6 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
1.1 3.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 2.9 GO:0005844 polysome(GO:0005844)
0.0 2.9 GO:0005884 actin filament(GO:0005884)
0.0 2.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 2.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 2.4 GO:0000793 condensed chromosome(GO:0000793)
0.1 2.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.7 2.0 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 2.0 GO:0002080 acrosomal membrane(GO:0002080)
0.5 1.9 GO:0043259 laminin-10 complex(GO:0043259)
0.1 1.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 8.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.5 5.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 4.7 GO:0005525 GTP binding(GO:0005525)
0.2 4.5 GO:0003746 translation elongation factor activity(GO:0003746)
1.4 4.2 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.3 4.0 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.4 3.8 GO:0070700 BMP receptor binding(GO:0070700)
1.2 3.7 GO:0005110 frizzled-2 binding(GO:0005110)
0.5 3.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 3.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 3.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 3.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 3.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 2.5 GO:0042610 CD8 receptor binding(GO:0042610)
0.4 2.4 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 2.4 GO:0045182 translation regulator activity(GO:0045182)
0.1 2.1 GO:0005109 frizzled binding(GO:0005109)
0.0 2.1 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 2.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 2.0 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 3.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 3.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.7 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 2.5 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 2.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 2.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 1.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 0.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 4.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 3.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 2.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.4 2.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 2.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.3 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.2 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation