Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 1.030

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.688.7e-07Click!
Prrx2mm10_v2_chr2_+_30845059_308450590.434.6e-03Click!
Shox2mm10_v2_chr3_-_66981279_669813180.163.1e-01Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 24.738 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_+_20737306 20.047 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr14_-_48665098 16.360 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr3_+_159839729 14.508 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr8_-_61902669 13.066 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr3_+_55782500 12.073 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr2_+_71528657 11.382 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr17_+_34592248 11.293 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr3_+_125404292 11.139 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chrX_-_60893430 11.134 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr3_+_125404072 11.118 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr2_-_168767136 10.848 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr7_-_49636847 10.529 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr14_-_118052235 9.908 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr2_-_168767029 9.827 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr6_-_147264124 8.822 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr2_+_25372315 8.682 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr2_-_72986716 8.126 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr12_+_38780817 7.977 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr12_+_38780284 7.946 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 31.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
3.1 24.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.1 20.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 18.5 GO:0048706 embryonic skeletal system development(GO:0048706)
4.5 17.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
4.8 14.5 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.7 13.1 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.0 11.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
3.8 11.4 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.4 11.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.6 11.1 GO:0007530 sex determination(GO:0007530)
0.7 10.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.7 9.9 GO:0006570 tyrosine metabolic process(GO:0006570)
0.8 7.6 GO:0010587 miRNA catabolic process(GO:0010587)
1.3 7.5 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
1.1 7.5 GO:0019532 oxalate transport(GO:0019532)
0.9 7.2 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.1 6.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.5 6.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 6.7 GO:0006270 DNA replication initiation(GO:0006270)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 118.6 GO:0005634 nucleus(GO:0005634)
0.1 20.6 GO:0000792 heterochromatin(GO:0000792)
0.4 14.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 13.1 GO:0002102 podosome(GO:0002102)
0.0 12.0 GO:0005794 Golgi apparatus(GO:0005794)
0.4 9.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 9.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 7.0 GO:0016323 basolateral plasma membrane(GO:0016323)
1.1 6.9 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 6.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 5.5 GO:0043198 dendritic shaft(GO:0043198)
0.4 4.6 GO:0005915 zonula adherens(GO:0005915)
0.3 4.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 4.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.6 3.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.6 3.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.7 2.7 GO:0060187 cell pole(GO:0060187)
0.0 2.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 2.6 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 76.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 36.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
3.1 21.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 19.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
1.6 15.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 15.0 GO:0003779 actin binding(GO:0003779)
0.1 12.1 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.3 11.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 10.7 GO:0000287 magnesium ion binding(GO:0000287)
0.8 9.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.9 8.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.7 7.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.6 6.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.9 6.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 6.1 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 5.5 GO:0003774 motor activity(GO:0003774)
0.4 5.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 4.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 4.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 4.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 31.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 21.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 11.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 8.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 7.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 6.7 PID_BMP_PATHWAY BMP receptor signaling
0.2 6.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 6.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 4.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 4.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 3.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.6 PID_MYC_PATHWAY C-MYC pathway
0.1 2.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 21.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 12.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 9.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 8.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.3 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 3.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 3.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 2.9 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 2.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 1.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.6 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.4 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 1.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.3 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation