Motif ID: Wrnip1_Mta3_Rcor1

Z-value: 2.951

Transcription factors associated with Wrnip1_Mta3_Rcor1:

Gene SymbolEntrez IDGene Name
Mta3 ENSMUSG00000055817.11 Mta3
Rcor1 ENSMUSG00000037896.11 Rcor1
Wrnip1 ENSMUSG00000021400.6 Wrnip1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rcor1mm10_v2_chr12_+_111039334_111039400-0.612.2e-05Click!
Mta3mm10_v2_chr17_+_83706170_83706200-0.067.2e-01Click!
Wrnip1mm10_v2_chr13_+_32802007_328021520.047.9e-01Click!


Activity profile for motif Wrnip1_Mta3_Rcor1.

activity profile for motif Wrnip1_Mta3_Rcor1


Sorted Z-values histogram for motif Wrnip1_Mta3_Rcor1

Sorted Z-values for motif Wrnip1_Mta3_Rcor1



Network of associatons between targets according to the STRING database.



First level regulatory network of Wrnip1_Mta3_Rcor1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_115994953 19.322 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr7_+_36698002 10.825 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chr4_-_68954351 10.677 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr7_-_34812677 10.393 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr4_+_138454305 9.913 ENSMUST00000050918.3
 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr10_-_120476469 9.823 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr7_+_123982799 9.614 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr16_+_92498122 8.995 ENSMUST00000023670.3
 Clic6
chloride intracellular channel 6
chr2_+_164562579 8.901 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr11_-_95587691 8.803 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr12_+_112146187 8.101 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr2_+_31640037 8.084 ENSMUST00000113470.2
 Prdm12
PR domain containing 12
chr11_-_4746778 8.082 ENSMUST00000009219.2
 Cabp7
calcium binding protein 7
chr18_-_38211957 7.601 ENSMUST00000159405.1
ENSMUST00000160721.1
 Pcdh1

protocadherin 1

chr18_+_20665250 7.509 ENSMUST00000075312.3
 Ttr
transthyretin
chr6_+_7555053 7.394 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr1_-_171196229 7.136 ENSMUST00000111332.1
 Pcp4l1
Purkinje cell protein 4-like 1
chr5_-_106458440 7.064 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr15_-_85581809 6.879 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr15_-_84447037 6.855 ENSMUST00000080751.2
 1810041L15Rik
RIKEN cDNA 1810041L15 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,505 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 26.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.6 23.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.6 21.2 GO:0045806 negative regulation of endocytosis(GO:0045806)
1.1 20.1 GO:0021516 dorsal spinal cord development(GO:0021516)
1.0 19.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
2.1 18.7 GO:1990845 adaptive thermogenesis(GO:1990845)
1.7 18.3 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.9 16.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.4 16.6 GO:0032543 mitochondrial translation(GO:0032543)
0.6 16.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.4 16.0 GO:0022900 electron transport chain(GO:0022900)
0.7 15.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 14.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
1.1 14.5 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
1.3 14.4 GO:0031645 negative regulation of neurological system process(GO:0031645)
4.7 14.0 GO:0097402 neuroblast migration(GO:0097402)
0.5 13.7 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.6 13.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.3 13.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.9 13.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 497 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 429.9 GO:0005576 extracellular region(GO:0005576)
0.2 69.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.9 64.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 59.1 GO:0005739 mitochondrion(GO:0005739)
0.0 57.8 GO:0016021 integral component of membrane(GO:0016021)
0.1 50.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.9 48.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.7 39.5 GO:0015934 large ribosomal subunit(GO:0015934)
0.7 36.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 32.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.9 27.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 25.8 GO:0043204 perikaryon(GO:0043204)
0.2 22.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.7 21.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.6 20.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.3 20.5 GO:0072562 blood microparticle(GO:0072562)
0.2 19.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 18.8 GO:0005581 collagen trimer(GO:0005581)
1.3 18.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 15.9 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 741 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 157.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 106.4 GO:0003924 GTPase activity(GO:0003924)
0.8 35.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.6 30.2 GO:0048487 beta-tubulin binding(GO:0048487)
0.7 28.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.4 27.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
1.1 26.3 GO:0003746 translation elongation factor activity(GO:0003746)
1.7 26.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.7 25.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.1 25.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 24.0 GO:0008236 serine-type peptidase activity(GO:0008236)
0.8 23.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 23.3 GO:0019210 kinase inhibitor activity(GO:0019210)
1.7 21.5 GO:0001972 retinoic acid binding(GO:0001972)
1.3 19.1 GO:0015026 coreceptor activity(GO:0015026)
0.5 18.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.4 18.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.5 17.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 17.6 GO:0005518 collagen binding(GO:0005518)
1.9 17.2 GO:0070324 thyroid hormone binding(GO:0070324)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 50.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 49.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.6 42.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 30.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.8 30.4 PID_ALK1_PATHWAY ALK1 signaling events
0.4 28.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.8 28.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 26.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.7 23.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.3 21.0 PID_P73PATHWAY p73 transcription factor network
0.5 20.0 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.6 18.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 18.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.6 18.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 18.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.3 17.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.5 16.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.6 16.3 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.6 16.2 PID_ARF_3PATHWAY Arf1 pathway
0.4 14.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 217 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 112.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.9 68.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.8 47.5 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.8 39.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
1.0 37.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.0 36.2 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.4 35.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.8 31.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 30.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.7 29.8 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.5 28.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.3 28.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 26.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 23.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
1.0 23.0 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.2 22.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
1.4 22.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 22.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.6 21.9 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.9 21.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions