Motif ID: Yy1_Yy2

Z-value: 3.519

Transcription factors associated with Yy1_Yy2:

Gene SymbolEntrez IDGene Name
Yy1 ENSMUSG00000021264.11 Yy1
Yy2 ENSMUSG00000091736.2 Yy2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Yy2mm10_v2_chrX_-_157598642_157598655-0.552.2e-04Click!
Yy1mm10_v2_chr12_+_108792946_1087929880.143.7e-01Click!


Activity profile for motif Yy1_Yy2.

activity profile for motif Yy1_Yy2


Sorted Z-values histogram for motif Yy1_Yy2

Sorted Z-values for motif Yy1_Yy2



Network of associatons between targets according to the STRING database.



First level regulatory network of Yy1_Yy2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22163299 23.122 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr16_+_30065333 21.713 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr19_+_25610533 19.198 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr11_+_94741782 15.494 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr17_-_23829095 15.415 ENSMUST00000069579.5
 Tceb2
transcription elongation factor B (SIII), polypeptide 2
chr10_-_42583628 13.321 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr3_-_90213577 13.280 ENSMUST00000170122.2
 Rps27
ribosomal protein S27
chr19_-_50030735 12.837 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr7_-_78783026 11.819 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr11_+_75732869 11.668 ENSMUST00000067664.3
 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr1_-_186117251 11.399 ENSMUST00000045388.7
 Lyplal1
lysophospholipase-like 1
chr14_-_20181773 11.377 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr11_+_117849286 11.371 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr14_-_54617993 11.151 ENSMUST00000022803.4
 Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr19_-_59170978 11.005 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr8_-_107263248 10.882 ENSMUST00000080443.6
 Rps18-ps3
ribosomal protein S18, pseudogene 3
chr9_-_97018823 10.689 ENSMUST00000055433.4
 Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr10_-_128549102 10.616 ENSMUST00000176906.1
 Rpl41
ribosomal protein L41
chr3_+_146121655 10.506 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr13_-_23551648 10.482 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 895 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 113.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.2 74.3 GO:0002181 cytoplasmic translation(GO:0002181)
1.0 62.3 GO:0032543 mitochondrial translation(GO:0032543)
1.2 52.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
2.2 51.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
4.6 32.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
2.0 31.6 GO:0043248 proteasome assembly(GO:0043248)
7.9 31.4 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.4 30.9 GO:0006413 translational initiation(GO:0006413)
1.0 25.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 24.3 GO:0051028 mRNA transport(GO:0051028)
2.3 23.2 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.7 22.3 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
1.3 21.6 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.6 20.1 GO:0006270 DNA replication initiation(GO:0006270)
1.8 20.0 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
4.0 19.9 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
1.6 19.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.7 19.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.8 19.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 368 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 152.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
3.1 100.8 GO:0000788 nuclear nucleosome(GO:0000788)
1.9 100.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.5 89.8 GO:0044391 ribosomal subunit(GO:0044391)
1.5 72.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 62.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.7 55.0 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 54.0 GO:0005730 nucleolus(GO:0005730)
1.3 49.1 GO:0000786 nucleosome(GO:0000786)
1.7 39.9 GO:0005839 proteasome core complex(GO:0005839)
0.4 36.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 35.0 GO:0005615 extracellular space(GO:0005615)
5.5 27.7 GO:0032133 chromosome passenger complex(GO:0032133)
0.3 25.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.7 24.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.6 23.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.1 23.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 21.0 GO:0005759 mitochondrial matrix(GO:0005759)
1.4 20.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.4 19.3 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 544 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 349.9 GO:0003735 structural constituent of ribosome(GO:0003735)
1.7 82.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.8 44.5 GO:0003743 translation initiation factor activity(GO:0003743)
1.7 38.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 37.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
1.3 36.4 GO:0008432 JUN kinase binding(GO:0008432)
1.2 33.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 32.0 GO:0003723 RNA binding(GO:0003723)
1.4 29.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.6 26.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 24.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 24.1 GO:0046982 protein heterodimerization activity(GO:0046982)
2.7 23.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 23.4 GO:0008536 Ran GTPase binding(GO:0008536)
1.0 22.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.0 21.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.5 21.0 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.6 20.5 GO:0008307 structural constituent of muscle(GO:0008307)
1.7 19.2 GO:0050815 phosphoserine binding(GO:0050815)
1.4 17.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 61.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 54.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
1.0 43.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.7 39.9 PID_PLK1_PATHWAY PLK1 signaling events
1.0 36.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
1.2 34.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.5 32.0 PID_E2F_PATHWAY E2F transcription factor network
0.4 29.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.7 28.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.5 21.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.5 20.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.6 18.7 PID_ATR_PATHWAY ATR signaling pathway
0.5 18.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 17.6 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 16.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7 16.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.9 15.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.6 15.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
1.1 14.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6 13.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 261.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
2.9 150.1 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
1.5 106.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
1.8 99.4 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.7 62.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.8 39.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.4 37.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
2.0 35.9 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.4 33.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.9 29.8 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.4 28.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
1.0 27.3 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.7 27.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
1.0 26.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
1.2 25.2 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.3 22.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.6 22.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.6 21.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.4 20.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.6 20.5 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC