Motif ID: Zbtb12

Z-value: 0.507


Transcription factors associated with Zbtb12:

Gene SymbolEntrez IDGene Name
Zbtb12 ENSMUSG00000049823.8 Zbtb12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_348945730.144.0e-01Click!


Activity profile for motif Zbtb12.

activity profile for motif Zbtb12


Sorted Z-values histogram for motif Zbtb12

Sorted Z-values for motif Zbtb12



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb12

PNG image of the network

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Top targets:


Showing 1 to 20 of 54 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_59260878 3.541 ENSMUST00000026084.3
 Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr11_-_12027958 3.412 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr14_-_103844173 2.995 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr17_-_15375969 2.587 ENSMUST00000014917.7
 Dll1
delta-like 1 (Drosophila)
chr6_-_124814288 2.268 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chr3_+_88081997 1.835 ENSMUST00000071812.5
 Iqgap3
IQ motif containing GTPase activating protein 3
chr3_-_84155762 1.483 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr17_-_27029009 1.443 ENSMUST00000078691.5
 Bak1
BCL2-antagonist/killer 1
chr11_+_54902743 1.419 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr11_+_54902917 1.372 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr13_+_104229366 1.248 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr8_-_45382198 1.109 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr5_+_92603039 1.092 ENSMUST00000050952.3
 Stbd1
starch binding domain 1
chr4_+_32983417 1.056 ENSMUST00000084747.5
 Rragd
Ras-related GTP binding D
chr11_-_88718078 0.972 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chr18_-_70472429 0.960 ENSMUST00000067556.3
 4930503L19Rik
RIKEN cDNA 4930503L19 gene
chr6_+_90462562 0.736 ENSMUST00000032174.5
 Klf15
Kruppel-like factor 15
chr2_-_28916668 0.691 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr4_-_151057933 0.593 ENSMUST00000030797.3
 Vamp3
vesicle-associated membrane protein 3
chr9_+_22411515 0.591 ENSMUST00000058868.7
 9530077C05Rik
RIKEN cDNA 9530077C05 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.5 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.4 3.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.0 3.0 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.1 2.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.9 2.6 GO:0001757 somite specification(GO:0001757) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.8 2.3 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 1.8 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 1.5 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.5 1.4 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 1.1 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.1 1.1 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.3 1.0 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.0 0.7 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.7 GO:0030901 midbrain development(GO:0030901)
0.0 0.6 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 0.5 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.4 GO:0033762 response to glucagon(GO:0033762)
0.0 0.4 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.1 0.3 GO:0051012 microtubule sliding(GO:0051012)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.5 GO:0031045 dense core granule(GO:0031045)
0.0 3.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 1.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.0 0.6 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.4 GO:0045178 basal part of cell(GO:0045178)
0.0 0.3 GO:0044447 axoneme part(GO:0044447)
0.1 0.2 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0042405 nuclear inclusion body(GO:0042405)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.5 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
1.0 3.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.3 2.8 GO:0008430 selenium binding(GO:0008430)
0.1 2.7 GO:0005158 insulin receptor binding(GO:0005158)
0.2 2.6 GO:0030957 Tat protein binding(GO:0030957)
0.2 2.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4 1.8 GO:0032027 myosin light chain binding(GO:0032027)
0.1 1.4 GO:0051400 BH domain binding(GO:0051400)
0.3 1.1 GO:2001069 glycogen binding(GO:2001069)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.2 GO:0070736 protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736)
0.0 0.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.4 PID_IGF1_PATHWAY IGF1 pathway
0.0 2.6 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 3.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 2.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.4 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome