Motif ID: Zbtb14

Z-value: 1.921


Transcription factors associated with Zbtb14:

Gene SymbolEntrez IDGene Name
Zbtb14 ENSMUSG00000049672.8 Zbtb14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb14mm10_v2_chr17_+_69383768_693838400.409.7e-03Click!


Activity profile for motif Zbtb14.

activity profile for motif Zbtb14


Sorted Z-values histogram for motif Zbtb14

Sorted Z-values for motif Zbtb14



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb14

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_63212514 12.046 ENSMUST00000032738.5
 Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
chr1_-_132741750 9.373 ENSMUST00000094569.4
ENSMUST00000163770.1
 Nfasc

neurofascin

chr11_+_104231573 8.294 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_-_102296618 8.282 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr1_+_63445842 8.144 ENSMUST00000087374.3
ENSMUST00000114107.1
ENSMUST00000182642.1
 Adam23


a disintegrin and metallopeptidase domain 23


chr11_-_6065737 8.124 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr10_+_13966268 8.071 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr11_+_104231515 7.944 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_-_6065538 7.941 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr7_-_27396542 7.619 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr11_+_104231465 7.262 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr2_-_104410334 7.207 ENSMUST00000089726.3
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr15_+_83779975 6.866 ENSMUST00000163723.1
 Mpped1
metallophosphoesterase domain containing 1
chr11_+_104231390 6.763 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr11_+_84129649 6.708 ENSMUST00000133811.1
 Acaca
acetyl-Coenzyme A carboxylase alpha
chrX_+_159627534 6.389 ENSMUST00000073094.3
 Sh3kbp1
SH3-domain kinase binding protein 1
chr11_+_7063423 6.379 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr9_+_103112072 6.277 ENSMUST00000035155.6
 Rab6b
RAB6B, member RAS oncogene family
chr10_+_58813359 6.244 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr9_-_24503127 6.159 ENSMUST00000142064.1
ENSMUST00000170356.1
 Dpy19l1

dpy-19-like 1 (C. elegans)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 444 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 29.9 GO:1900034 regulation of cellular response to heat(GO:1900034)
3.6 21.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
5.4 16.1 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.5 14.4 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
4.0 12.0 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
2.4 9.7 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.2 9.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.5 9.0 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.3 8.9 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
0.2 8.7 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.5 8.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 8.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 8.3 GO:0016578 histone deubiquitination(GO:0016578)
0.2 8.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.6 7.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.3 7.5 GO:0003350 pulmonary myocardium development(GO:0003350)
0.5 7.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.5 7.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.3 7.5 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.9 7.4 GO:0032020 ISG15-protein conjugation(GO:0032020)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 30.3 GO:0045298 tubulin complex(GO:0045298)
0.1 22.1 GO:0099572 postsynaptic specialization(GO:0099572)
0.3 21.2 GO:0031594 neuromuscular junction(GO:0031594)
0.4 14.4 GO:0051233 spindle midzone(GO:0051233)
0.7 13.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
2.1 12.7 GO:0008091 spectrin(GO:0008091)
1.1 12.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.3 11.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.4 10.5 GO:0033268 node of Ranvier(GO:0033268)
0.1 10.2 GO:0055037 recycling endosome(GO:0055037)
2.5 10.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 8.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
1.7 8.7 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 8.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.5 8.3 GO:0000124 SAGA complex(GO:0000124)
0.4 8.1 GO:0030139 endocytic vesicle(GO:0030139)
0.6 7.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 7.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.1 7.4 GO:0070695 FHF complex(GO:0070695)
0.1 7.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 277 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 30.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.7 17.9 GO:0030506 ankyrin binding(GO:0030506)
0.2 17.7 GO:0019905 syntaxin binding(GO:0019905)
0.7 17.6 GO:0043274 phospholipase binding(GO:0043274)
0.1 15.1 GO:0017137 Rab GTPase binding(GO:0017137)
1.2 12.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.5 11.7 GO:0031489 myosin V binding(GO:0031489)
0.5 11.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 10.4 GO:0005158 insulin receptor binding(GO:0005158)
0.2 10.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
2.0 9.8 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 9.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 9.5 GO:0005509 calcium ion binding(GO:0005509)
1.0 9.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 9.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 9.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
1.5 9.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.8 9.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.4 8.6 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.6 8.6 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 30.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 20.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.1 18.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.7 15.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 13.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 12.4 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.2 10.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 9.2 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 7.1 PID_P73PATHWAY p73 transcription factor network
0.1 5.8 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.2 5.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 4.8 PID_IGF1_PATHWAY IGF1 pathway
0.1 4.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 4.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 4.2 PID_INSULIN_PATHWAY Insulin Pathway
0.1 3.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 3.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.7 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 3.5 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 31.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.8 20.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.5 18.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 18.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 15.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.0 12.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
1.3 12.0 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.3 9.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.6 7.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 7.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 7.2 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.2 6.8 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 6.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 6.5 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 6.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 6.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 6.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 5.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 5.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 5.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling