Motif ID: Zbtb18

Z-value: 0.867


Transcription factors associated with Zbtb18:

Gene SymbolEntrez IDGene Name
Zbtb18 ENSMUSG00000063659.6 Zbtb18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb18mm10_v2_chr1_+_177445660_177445821-0.594.7e-05Click!


Activity profile for motif Zbtb18.

activity profile for motif Zbtb18


Sorted Z-values histogram for motif Zbtb18

Sorted Z-values for motif Zbtb18



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb18

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_7555053 4.872 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr17_-_73710415 3.562 ENSMUST00000112591.2
ENSMUST00000024858.5
 Galnt14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14

chr2_+_165655237 2.761 ENSMUST00000063433.7
 Eya2
eyes absent 2 homolog (Drosophila)
chr18_+_50051702 2.706 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr13_+_13784278 2.313 ENSMUST00000021734.7
 Gng4
guanine nucleotide binding protein (G protein), gamma 4
chr5_-_30945393 2.292 ENSMUST00000031051.6
 Cgref1
cell growth regulator with EF hand domain 1
chr4_+_43957678 2.270 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr12_+_109743787 2.243 ENSMUST00000183068.1
 Mirg
miRNA containing gene
chr1_+_137928100 2.225 ENSMUST00000054333.2
 A130050O07Rik
RIKEN cDNA A130050O07 gene
chr14_-_20181773 2.140 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr4_-_141598206 2.128 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr4_+_43957401 2.120 ENSMUST00000030202.7
 Glipr2
GLI pathogenesis-related 2
chr9_-_20976762 2.104 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr6_+_5390387 2.101 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr11_-_107794557 2.001 ENSMUST00000021066.3
 Cacng4
calcium channel, voltage-dependent, gamma subunit 4
chr9_-_48911067 1.962 ENSMUST00000003826.7
 Htr3a
5-hydroxytryptamine (serotonin) receptor 3A
chr7_+_122671401 1.924 ENSMUST00000182095.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr3_+_134236483 1.888 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr18_+_20665250 1.873 ENSMUST00000075312.3
 Ttr
transthyretin
chr10_+_127514939 1.849 ENSMUST00000035735.9
 Ndufa4l2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.6 4.9 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 4.1 GO:0030308 negative regulation of cell growth(GO:0030308)
0.1 3.5 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 3.0 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.3 2.8 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 2.8 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 2.7 GO:0032611 interleukin-1 beta production(GO:0032611)
0.2 2.6 GO:1902993 positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.4 2.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.2 2.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 2.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 2.1 GO:0032414 positive regulation of ion transmembrane transporter activity(GO:0032414)
0.2 2.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 1.9 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 1.7 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2 1.7 GO:0060539 diaphragm development(GO:0060539)
0.1 1.7 GO:0032060 bleb assembly(GO:0032060)
0.3 1.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 1.6 GO:0046596 regulation of viral entry into host cell(GO:0046596)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.7 GO:0005882 intermediate filament(GO:0005882)
0.0 2.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.3 GO:0008021 synaptic vesicle(GO:0008021)
0.4 2.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.1 1.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 1.7 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.5 GO:0005657 replication fork(GO:0005657)
0.1 1.4 GO:0032009 early phagosome(GO:0032009)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.1 GO:0097440 apical dendrite(GO:0097440)
0.0 1.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 3.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 3.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)
0.0 3.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 2.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 2.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 2.1 GO:0031005 filamin binding(GO:0031005)
0.4 2.0 GO:0099589 serotonin receptor activity(GO:0099589)
0.2 2.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 1.9 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 1.9 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 1.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.5 GO:0045182 translation regulator activity(GO:0045182)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.1 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.3 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID_SHP2_PATHWAY SHP2 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 5.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 2.3 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.1 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.1 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 2.0 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 2.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.1 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.1 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.8 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)