Motif ID: Zbtb4

Z-value: 0.579


Transcription factors associated with Zbtb4:

Gene SymbolEntrez IDGene Name
Zbtb4 ENSMUSG00000018750.8 Zbtb4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb4mm10_v2_chr11_+_69765970_697660270.048.2e-01Click!


Activity profile for motif Zbtb4.

activity profile for motif Zbtb4


Sorted Z-values histogram for motif Zbtb4

Sorted Z-values for motif Zbtb4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 4.634 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr5_+_139543889 2.620 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_+_47244359 2.007 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr5_+_147957310 1.273 ENSMUST00000085558.4
ENSMUST00000129092.1
 Mtus2

microtubule associated tumor suppressor candidate 2

chr19_+_41482632 1.247 ENSMUST00000067795.5
 Lcor
ligand dependent nuclear receptor corepressor
chr9_+_75071579 1.158 ENSMUST00000136731.1
 Myo5a
myosin VA
chr9_+_75071386 1.154 ENSMUST00000155282.2
 Myo5a
myosin VA
chr5_+_65764073 1.090 ENSMUST00000138239.1
ENSMUST00000087264.3
 N4bp2

NEDD4 binding protein 2

chr8_-_57962564 1.013 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr7_+_16175085 0.931 ENSMUST00000176342.1
ENSMUST00000177540.1
 Meis3

Meis homeobox 3

chr15_+_100761741 0.903 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chrX_+_143664365 0.899 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
 Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr11_+_55213783 0.898 ENSMUST00000108867.1
 Slc36a1
solute carrier family 36 (proton/amino acid symporter), member 1
chr4_+_12906838 0.897 ENSMUST00000143186.1
ENSMUST00000183345.1
 Triqk

triple QxxK/R motif containing

chr8_-_122678653 0.887 ENSMUST00000134045.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr4_+_43381979 0.886 ENSMUST00000035645.5
ENSMUST00000144911.1
 Rusc2

RUN and SH3 domain containing 2

chr5_-_97111589 0.878 ENSMUST00000069453.2
ENSMUST00000112968.1
 Paqr3

progestin and adipoQ receptor family member III

chr6_+_58831456 0.872 ENSMUST00000141600.1
ENSMUST00000122981.1
 Herc3

hect domain and RLD 3

chr2_-_4141128 0.862 ENSMUST00000154360.1
ENSMUST00000141488.1
ENSMUST00000155091.1
 1700080N15Rik


RIKEN cDNA 1700080N15 gene


chr7_-_25005895 0.856 ENSMUST00000102858.3
ENSMUST00000080882.6
 Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.6 2.8 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.3 2.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 2.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.4 2.0 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 1.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 1.6 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.3 1.2 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.3 1.0 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 1.0 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 1.0 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.9 GO:0015808 L-alanine transport(GO:0015808)
0.1 0.9 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 0.9 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.9 GO:0036376 sodium ion export from cell(GO:0036376)
0.0 0.9 GO:0015693 magnesium ion transport(GO:0015693)
0.3 0.8 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.1 0.8 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.0 0.8 GO:0008210 androgen metabolic process(GO:0008209) estrogen metabolic process(GO:0008210)
0.0 0.8 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.1 GO:0042642 actomyosin, myosin complex part(GO:0042642)
0.1 2.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.0 GO:0042587 glycogen granule(GO:0042587)
0.1 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 0.8 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 0.8 GO:0043203 axon hillock(GO:0043203)
0.1 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.6 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.0 0.5 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.5 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.3 GO:0070985 TFIIK complex(GO:0070985)
0.1 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.3 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 1.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.6 GO:0032183 SUMO binding(GO:0032183)
0.2 1.3 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.4 1.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 1.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.0 GO:0046790 virion binding(GO:0046790)
0.3 0.9 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.9 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.9 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 0.8 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 0.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 0.7 GO:0042806 fucose binding(GO:0042806)
0.1 0.7 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 0.6 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.6 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.1 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.3 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 1.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.6 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.4 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha