Motif ID: Zbtb7a

Z-value: 0.931


Transcription factors associated with Zbtb7a:

Gene SymbolEntrez IDGene Name
Zbtb7a ENSMUSG00000035011.9 Zbtb7a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7amm10_v2_chr10_+_81136534_811366080.342.8e-02Click!


Activity profile for motif Zbtb7a.

activity profile for motif Zbtb7a


Sorted Z-values histogram for motif Zbtb7a

Sorted Z-values for motif Zbtb7a



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_107036156 3.891 ENSMUST00000052718.3
 Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr7_+_96210107 3.858 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr9_-_44234014 3.798 ENSMUST00000037644.6
 Cbl
Casitas B-lineage lymphoma
chr11_+_75532127 2.995 ENSMUST00000127226.1
 Slc43a2
solute carrier family 43, member 2
chr18_+_32938955 2.934 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr8_-_34965631 2.723 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr11_-_107915041 2.713 ENSMUST00000039071.2
 Cacng5
calcium channel, voltage-dependent, gamma subunit 5
chr11_+_75531690 2.700 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr8_-_11008458 2.625 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr11_+_24076529 2.603 ENSMUST00000148087.1
 Gm12063
predicted gene 12063
chr4_-_123664725 2.559 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1
chr9_+_67840386 2.487 ENSMUST00000077879.5
 Vps13c
vacuolar protein sorting 13C (yeast)
chrX_+_159697308 2.486 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr1_-_155417394 2.460 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chrX_+_71364901 2.452 ENSMUST00000132837.1
 Mtmr1
myotubularin related protein 1
chr15_-_72546279 2.443 ENSMUST00000044624.6
 Kcnk9
potassium channel, subfamily K, member 9
chr7_+_49246812 2.351 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr2_-_29253001 2.261 ENSMUST00000071201.4
 Ntng2
netrin G2
chr1_-_154725920 2.238 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr15_-_98567630 2.226 ENSMUST00000012104.6
 Ccnt1
cyclin T1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 226 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 GO:0015807 L-amino acid transport(GO:0015807)
0.4 6.6 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.2 4.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 4.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 4.2 GO:1901525 negative regulation of macromitophagy(GO:1901525)
1.0 3.9 GO:0060912 cardiac cell fate specification(GO:0060912)
0.1 3.9 GO:0046856 phospholipid dephosphorylation(GO:0046839) phosphatidylinositol dephosphorylation(GO:0046856)
0.6 3.8 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 3.8 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.5 3.7 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 3.5 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
1.1 3.4 GO:0070650 actin filament bundle distribution(GO:0070650)
0.6 2.9 GO:1990034 calcium ion export from cell(GO:1990034)
0.2 2.9 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.7 2.8 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.9 2.7 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.4 2.6 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.3 2.6 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.3 2.6 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 2.5 GO:0007520 myoblast fusion(GO:0007520)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0014069 postsynaptic density(GO:0014069)
0.1 6.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 5.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 5.0 GO:0005903 brush border(GO:0005903)
0.1 4.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 4.1 GO:0008021 synaptic vesicle(GO:0008021)
0.3 3.8 GO:0016600 flotillin complex(GO:0016600)
0.6 3.4 GO:0097513 myosin II filament(GO:0097513)
0.0 3.2 GO:0005923 bicellular tight junction(GO:0005923)
0.1 2.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 2.6 GO:0043209 myelin sheath(GO:0043209)
0.2 2.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.5 GO:0030139 endocytic vesicle(GO:0030139)
0.0 2.5 GO:0001650 fibrillar center(GO:0001650)
0.1 2.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.4 GO:0005774 vacuolar membrane(GO:0005774)
0.1 2.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.2 GO:0005811 lipid particle(GO:0005811)
0.2 2.1 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.4 6.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 4.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 4.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 4.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.2 4.0 GO:0050811 GABA receptor binding(GO:0050811)
0.6 3.9 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
1.3 3.8 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 3.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.3 3.7 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.2 3.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 3.3 GO:0008017 microtubule binding(GO:0008017)
0.2 2.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 2.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 2.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.6 2.3 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.2 2.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 5.0 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 3.2 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 3.1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.9 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 2.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 2.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.6 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 1.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.5 PID_ARF_3PATHWAY Arf1 pathway
0.1 1.5 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 1.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.3 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.1 PID_ALK2_PATHWAY ALK2 signaling events
0.1 1.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.1 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.1 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 6.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 5.0 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 4.3 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.3 3.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 3.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.3 3.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 3.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 3.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.6 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.3 2.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.7 2.0 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.0 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 1.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation