Motif ID: Zbtb7c

Z-value: 0.905


Transcription factors associated with Zbtb7c:

Gene SymbolEntrez IDGene Name
Zbtb7c ENSMUSG00000044646.8 Zbtb7c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7cmm10_v2_chr18_+_76059458_760595010.124.4e-01Click!


Activity profile for motif Zbtb7c.

activity profile for motif Zbtb7c


Sorted Z-values histogram for motif Zbtb7c

Sorted Z-values for motif Zbtb7c



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7c

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_32938955 5.670 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr4_-_22488296 4.662 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr2_-_29253001 4.586 ENSMUST00000071201.4
 Ntng2
netrin G2
chr10_-_127263346 4.440 ENSMUST00000099172.3
 Kif5a
kinesin family member 5A
chr8_+_40862379 4.061 ENSMUST00000098816.3
ENSMUST00000057784.8
ENSMUST00000141505.1
 Slc7a2


solute carrier family 7 (cationic amino acid transporter, y+ system), member 2


chr11_+_75531690 3.986 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr9_+_67840386 3.918 ENSMUST00000077879.5
 Vps13c
vacuolar protein sorting 13C (yeast)
chr11_+_104231573 3.911 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_+_104231465 3.874 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr16_+_11984581 3.736 ENSMUST00000170672.2
ENSMUST00000023138.7
 Shisa9

shisa homolog 9 (Xenopus laevis)

chr11_+_104231515 3.588 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_-_26210553 3.278 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr15_-_100599864 3.230 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr9_+_31280525 3.159 ENSMUST00000117389.1
 Prdm10
PR domain containing 10
chr9_+_100643755 2.975 ENSMUST00000133388.1
 Stag1
stromal antigen 1
chr3_+_107036156 2.783 ENSMUST00000052718.3
 Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr11_+_75532127 2.699 ENSMUST00000127226.1
 Slc43a2
solute carrier family 43, member 2
chr9_+_66350465 2.497 ENSMUST00000042824.6
 Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr12_-_76709997 2.299 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr1_-_21961581 2.270 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
 Kcnq5


potassium voltage-gated channel, subfamily Q, member 5



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 11.4 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 8.5 GO:0015807 L-amino acid transport(GO:0015807)
0.0 6.6 GO:0007409 axonogenesis(GO:0007409)
0.2 6.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 6.3 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.4 5.7 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.4 4.7 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.6 4.4 GO:0099640 axo-dendritic protein transport(GO:0099640)
1.4 4.1 GO:1902022 L-lysine transport(GO:1902022)
0.6 3.9 GO:1901525 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.0 3.9 GO:0007059 chromosome segregation(GO:0007059)
0.1 3.2 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 3.0 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 2.5 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.1 2.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 2.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.7 2.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.5 2.1 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.3 2.1 GO:0007296 vitellogenesis(GO:0007296)
0.3 2.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 11.4 GO:0045298 tubulin complex(GO:0045298)
0.0 8.7 GO:0016604 nuclear body(GO:0016604)
0.2 6.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 6.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 5.7 GO:0001650 fibrillar center(GO:0001650)
0.0 4.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 4.4 GO:0035253 ciliary rootlet(GO:0035253)
0.4 3.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.9 3.5 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 3.2 GO:0043209 myelin sheath(GO:0043209)
0.4 2.9 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 2.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.4 2.3 GO:0008091 spectrin(GO:0008091)
0.1 2.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.6 1.9 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.4 1.8 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 1.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 1.8 GO:0030137 COPI-coated vesicle(GO:0030137)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.4 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 8.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.5 5.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 4.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 4.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 4.2 GO:0042826 histone deacetylase binding(GO:0042826)
1.0 4.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 4.0 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.4 3.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 3.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 3.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 2.9 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 2.8 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 2.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 2.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.3 2.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 2.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 2.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.9 GO:0045503 dynein light chain binding(GO:0045503)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 11.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 6.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 5.7 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.4 3.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.6 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.9 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.6 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 11.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 5.7 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 5.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.4 REACTOME_KINESINS Genes involved in Kinesins
0.2 4.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 3.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 3.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.5 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis