Motif ID: Zfp219_Zfp740

Z-value: 1.274

Transcription factors associated with Zfp219_Zfp740:

Gene SymbolEntrez IDGene Name
Zfp219 ENSMUSG00000049295.10 Zfp219
Zfp740 ENSMUSG00000046897.10 Zfp740

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp740mm10_v2_chr15_+_102203639_1022037090.417.7e-03Click!
Zfp219mm10_v2_chr14_-_52020698_520207370.408.9e-03Click!


Activity profile for motif Zfp219_Zfp740.

activity profile for motif Zfp219_Zfp740


Sorted Z-values histogram for motif Zfp219_Zfp740

Sorted Z-values for motif Zfp219_Zfp740



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp219_Zfp740

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_134747241 7.731 ENSMUST00000015138.9
 Eln
elastin
chr1_-_56972437 7.474 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr7_-_78577771 7.471 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr7_-_78578308 6.847 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr10_-_127341583 6.405 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr15_+_57694651 5.930 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr10_-_127620922 5.839 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr11_-_69369377 5.705 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr10_-_127620960 4.999 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr16_+_44173271 4.912 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr2_-_36105271 4.859 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr16_+_43503607 4.779 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr7_+_127511976 4.750 ENSMUST00000098025.4
 Srcap
Snf2-related CREBBP activator protein
chr3_+_28263563 4.741 ENSMUST00000160307.2
ENSMUST00000159680.2
ENSMUST00000160518.1
ENSMUST00000162485.1
ENSMUST00000159308.1
ENSMUST00000162777.1
ENSMUST00000161964.1
 Tnik






TRAF2 and NCK interacting kinase






chr19_-_59170978 4.589 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr7_+_127777095 4.569 ENSMUST00000144406.1
 Setd1a
SET domain containing 1A
chr2_+_48949495 3.929 ENSMUST00000112745.1
 Mbd5
methyl-CpG binding domain protein 5
chr2_-_116065798 3.886 ENSMUST00000110907.1
ENSMUST00000110908.2
 Meis2

Meis homeobox 2

chr1_-_168431695 3.686 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chr6_+_4903350 3.685 ENSMUST00000175962.1
 Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 234 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 14.3 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.8 13.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
3.0 11.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.3 8.5 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 6.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
1.6 6.4 GO:0060032 notochord regression(GO:0060032)
1.2 6.2 GO:0007256 activation of JNKK activity(GO:0007256)
1.0 6.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
2.0 5.9 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.7 5.5 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.5 5.5 GO:0042572 retinol metabolic process(GO:0042572)
0.3 5.5 GO:1990403 embryonic brain development(GO:1990403)
0.5 5.4 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
1.2 4.9 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
1.0 4.9 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5 4.9 GO:0042118 endothelial cell activation(GO:0042118)
0.0 4.5 GO:0007051 spindle organization(GO:0007051)
1.1 4.4 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.2 4.4 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.5 4.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 13.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 10.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 9.5 GO:0016604 nuclear body(GO:0016604)
0.1 8.3 GO:0055037 recycling endosome(GO:0055037)
2.6 7.7 GO:0071953 elastic fiber(GO:0071953)
0.3 7.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5 6.4 GO:0097542 ciliary tip(GO:0097542)
1.2 5.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 5.5 GO:0035869 ciliary transition zone(GO:0035869)
0.3 5.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 5.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.1 GO:0032993 protein-DNA complex(GO:0032993)
0.1 5.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 4.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 4.1 GO:0010369 chromocenter(GO:0010369)
0.2 4.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.8 4.0 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 3.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.9 3.6 GO:0043259 laminin-10 complex(GO:0043259)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 14.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
4.0 11.9 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.1 9.0 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 8.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 7.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 6.6 GO:0070412 R-SMAD binding(GO:0070412)
0.4 6.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 6.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 6.0 GO:0008013 beta-catenin binding(GO:0008013)
0.8 5.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.1 5.4 GO:1990188 euchromatin binding(GO:1990188)
0.3 5.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.2 4.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 4.9 GO:0005003 ephrin receptor activity(GO:0005003)
0.8 4.5 GO:0045322 unmethylated CpG binding(GO:0045322)
0.6 4.5 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 4.5 GO:0001221 transcription cofactor binding(GO:0001221)
0.2 4.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.4 4.1 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.3 4.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.4 PID_SHP2_PATHWAY SHP2 signaling
0.3 11.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 8.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 8.3 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 6.7 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 6.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 5.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 4.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.5 4.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 3.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 3.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.9 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 2.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 2.7 PID_EPO_PATHWAY EPO signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 4.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 4.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 3.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 3.3 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 3.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 2.8 REACTOME_CHROMOSOME_MAINTENANCE Genes involved in Chromosome Maintenance
0.6 2.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.4 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 2.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.0 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.6 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.6 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling